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Ligand S-methyl-5-thio-alpha-D-ribose 1-phosphate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

methionine metabolism

KEGG

Biosynthesis of plant secondary metabolites, Cysteine and methionine metabolism

MetaCyc

S-methyl-5'-thioadenosine degradation I, S-methyl-5'-thioadenosine degradation II, S-methyl-5'-thioadenosine degradation III, S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I, S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II, S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III more

Show all BRENDA pathways known for S-methyl-5-thio-alpha-D-ribose 1-phosphate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.1.23

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate

727025, 705716, 728588, 760727, 762331, 761764

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

5'-deoxy-5'-methylthioadenosine + phosphate = adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.1

5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.1

2 entries

2.4.2.28

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

2.4.2.44

S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

2.7.1.100

ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.1.23

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate

727025, 705716, 728588, 760727, 762331, 761764

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Product in Enzyme-catalyzed Reactions (9 results)

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Show Product (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

5'-deoxy-5'-methylthioadenosine + phosphate = adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.1

5'-methylthioadenosine + phosphate = adenine + 5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.1

5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.28

5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.28

5'-methylthioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

2.4.2.28

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

2.4.2.44

5'-methylthioinosine + phosphate = hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate

0

-

2.4.2.44

S-methyl-5'-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

2.4.2.1

3 entries

2.4.2.28

3 entries

2.4.2.44

2 entries

2.7.1.100

ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.3.1.23

13

-

pH 8.1, 35°C

760727

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.3.1.23

0.138

-

pH 8.1, 35°C

760727

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

705716

19620624

A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme

2009

Kabuyama, Y.; Litman, E.S.; Templeton, P.D.; Metzner, S.I.; Witze, E.S.; Argast, G.M.; Langer, S.J.; Polvinen, K.; Shellman, Y.; Chan, D.; Shabb, J.B.; Fitzpatrick, J.E.; Resing, K.A.; Sousa, M.C.; Ahn, N.G.

Mol. Cell. Proteomics

8

2308-2320

727025

23859498

Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion

2013

Templeton, P.D.; Litman, E.S.; Metzner, S.I.; Ahn, N.G.; Sousa, M.C.

Biochemistry

52

5675-5684

728588

23285211

Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway

2012

Mary, C.; Duek, P.; Salleron, L.; Tienz, P.; Bumann, D.; Bairoch, A.; Lane, L.

PLoS ONE

7

e52877

760727

17690466

Enzymatic characterization of 5-methylthioribose 1-phosphate isomerase from Bacillus subtilis

2007

Saito, Y.; Ashida, H.; Kojima, C.; Tamura, H.; Matsumura, H.; Kai, Y.; Yokota, A.

Biosci. Biotechnol. Biochem.

71

2021-2028

761764

30471343

Structural insights into the catalytic mechanism of 5-methylthioribose 1-phosphate isomerase

2019

Gogoi, P.; Mordina, P.; Kanaujia, S.P.

J. Struct. Biol.

205

67-77

762331

18156470

Crystal structure of 5-methylthioribose 1-phosphate isomerase product complex from Bacillus subtilis implications for catalytic mechanism

2008

Tamura, H.; Saito, Y.; Ashida, H.; Inoue, T.; Kai, Y.; Yokota, A.; Matsumura, H.

Protein Sci.

17

126-135

Links to other databases for S-methyl-5-thio-alpha-D-ribose 1-phosphate

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Show Links (1 entry)

ChEBI

PubChem