Ligand C6-ceramide

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Basic Ligand Information

Molecular Structure
Picture of C6-ceramide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H47NO3
C6-ceramide
NPRJSFWNFTXXQC-QFWQFVLDSA-N
Synonyms:
alpha-OH-D-erythro-C6:0 ceramide, C6:0-ceramide, D-erythro-C6:0 ceramide, D-erythro-N-hexanoyl-sphingenine, N-hexanoyl-D-erythro-sphingenine, N-hexanoyl-sphingosine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
C6:0-ceramide + H2O = hexanoate + sphingosine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates in vivo and 2-3fold in vitro, blocked by protein phosphatase inhibitor-2, i.e. I-2, ceramide prevents retinoblastoma gene product pRb hyperphosphorylation by PP1 activation
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Enzyme Kinetic Parameters

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.04055
-
in tumor of NCI/ADR-RES
0.03
-
pH 7.2, 37°C, recombinant enzyme
0.2242
-
pH 9.0, 37°C

References & Links

Links to other databases for C6-ceramide

ChEBI
PubChem
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PubChem