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Ligand 5-fluoro-L-tryptophan

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Basic Ligand Information

Molecular Structure
Picture of 5-fluoro-L-tryptophan (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H11FN2O2
5-fluoro-L-tryptophan
INPQIVHQSQUEAJ-VIFPVBQESA-N
Synonyms:
5-fluoro-tryptophan, 5-Fluorotryptophan, L-5-fluoro-tryptophan, L-5-fluorotryptophan

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-fluoro-L-tryptophan + O2 = 5-fluoro-N-formyl-L-kynurenine
show the reaction diagram
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5-fluoro-L-tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-5-fluoro-L-tryptophan + FAD + 2 H2O
show the reaction diagram
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5-fluoro-L-tryptophan + O2 = ?
show the reaction diagram
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S-adenosyl-L-methionine + L-5-fluoro-tryptophan = S-adenosyl-L-homocysteine + L-5-fluoro-2-methyltryptophan
show the reaction diagram
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dimethylallyl diphosphate + 5-fluoro-L-tryptophan = diphosphate + 5-fluoro-4-(3-methylbut-2-enyl)-L-tryptophan
show the reaction diagram
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dimethylallyl diphosphate + 5-fluoro-L-tryptophan = diphosphate + 5-fluoro-7-(3-methylbut-2-enyl)-L-tryptophan
show the reaction diagram
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L-5-fluorotryptophan + 2-oxoglutarate = 3-indole-2-oxopropanoate + L-glutamate
show the reaction diagram
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5-fluoro-L-tryptophan = 5-fluorotryptamine + CO2
show the reaction diagram
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5-fluoro-L-tryptophan = ?
show the reaction diagram
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ATP + 5-fluorotryptophan + tRNATrp = AMP + diphosphate + 5-fluorotryptophyl-tRNATrp
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-serine + 5-fluoroindole = 5-fluorotryptophan + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (113 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.239
-
pH 7.8, 30°C

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.84
-
pH 7.8, 30°C
0.36
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00325
-
at 25°C in 0.2 M sodium phosphate buffer, pH 7.0

References & Links

Links to other databases for 5-fluoro-L-tryptophan

ChEBI
PubChem
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PubChem