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Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymic step of lipid A biosynthesis
1996
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Purification and properties of lipid A disaccharide synthase of Escherichia coli
1988
Radika, K.; Raetz, C.R.H.
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The C-terminal end of LpxC is required for degradation by the FtsH protease
2006
Fuehrer, F.; Langklotz, S.; Narberhaus, F.
Mol. Microbiol.
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A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
2001
Wang, W.; Maniar, M.; Jain, R.; Jacobs, J.; Trias, J.; Yuan, Z.
Anal. Biochem.
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Antibacterial activities and characterization of novel inhibitors of LpxC
2002
Clements, J.M.; Coignard, F.; Johnson, I.; Chandler, S.; Palan, S.; Waller, A.; Wijkmans, J.; Hunter, M.G.
Antimicrob. Agents Chemother.
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Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa
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Mdluli, K.E.; Witte, P.R.; Kline, T.; Barb, A.W.; Erwin, A.L.; Mansfield, B.E.; McClerren, A.L.; Pirrung, M.C.; Tumey, L.N.; Warrener, P.; Raetz, C.R.; Stover, C.K.
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Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine
1988
Anderson, M.S.; Robertson, A.D.; Macher, I.; Raetz, C.R.
Biochemistry
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UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme
1999
Jackman, J.E.; Raetz, C.R.; Fierke, C.A.
Biochemistry
38
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Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site
2001
Jackman, J.E.; Raetz, C.R.; Fierke, C.A.
Biochemistry
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Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design
2005
Coggins, B.E.; McClerren, A.L.; Jiang, L.; Li, X.; Rudolph, J.; Hindsgaul, O.; Raetz, C.R.; Zhou, P.
Biochemistry
44
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A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin
2005
McClerren, A.L.; Endsley, S.; Bowman, J.L.; Andersen, N.H.; Guan, Z.; Rudolph, J.; Raetz, C.R.
Biochemistry
44
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Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions
2006
Hernick, M.; Fierke, C.A.
Biochemistry
45
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Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis
2006
Hernick, M.; Fierke, C.A.
Biochemistry
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Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC
2009
Barb, A.W.; Leavy, T.M.; Robins, L.I.; Guan, Z.; Six, D.A.; Zhou, P.; Hangauer, M.J.; Bertozzi, C.R.; Raetz, C.R.
Biochemistry
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Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential
2008
Kadam, R.U.; Garg, D.; Roy, N.
Chem. Biol. Drug Des.
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High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties
2003
Pirrung, M.C.; Tumey, L.N.; McClerren, A.L.; Raetz, C.R.
J. Am. Chem. Soc.
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Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway
1997
Hyland, S.A.; Eveland, S.S.; Anderson, M.S.
J. Bacteriol.
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The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
1995
Young, K.; Silver, L.L.; Bramhill, D.; Cameron, P.; Eveland, S.S.; Raetz, C.R.; Hyland, S.A.; Anderson, M.S.
J. Biol. Chem.
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UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism
2005
Hernick, M.; Gennadios, H.A.; Whittington, D.A.; Rusche, K.M.; Christianson, D.W.; Fierke, C.A.
J. Biol. Chem.
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Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay
2009
Langsdorf, E.F.; Malikzay, A.; Lamarr, W.A.; Daubaras, D.; Kravec, C.; Zhang, R.; Hart, R.; Monsma, F.; Black, T.; Ozbal, C.C.; Miesel, L.; Lunn, C.A.
J. Biomol. Screen.
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Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups
2002
Pirrung, M.C.; Tumey, L.N.; Raetz, C.R.; Jackman, J.E.; Snehalatha, K.; McClerren, A.L.; Fierke, C.A.; Gantt, S.L.; Rusche, K.M.
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DFT investigation on the mechanism of the deacetylation reaction catalyzed by LpxC
2008
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J. Phys. Chem. B
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Structure of the LpxC deacetylase with a bound substrate-analog inhibitor
2003
Coggins, B.E.; Li, X.; McClerren, A.L.; Hindsgaul, O.; Raetz, C.R.; Zhou, P.
Nat. Struct. Biol.
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Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity
2010
Hernick, M.; Gattis, S.G.; Penner-Hahn, J.E.; Fierke, C.A.
Biochemistry
49
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A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA)
2013
Shapiro, A.B.; Ross, P.L.; Gao, N.; Livchak, S.; Kern, G.; Yang, W.; Andrews, B.; Thresher, J.
J. Biomol. Screen.
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Synthesis, structure, and SAR of tetrahydropyran-based LpxC inhibitors
2014
Murphy-Benenato, K.; Olivier, N.; Choy, A.; Ross, P.; Miller, M.; Thresher, J.; Gao, N.; Hale, M.
ACS Med. Chem. Lett.
5
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Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer
2013
Clayton, G.M.; Klein, D.J.; Rickert, K.W.; Patel, S.B.; Kornienko, M.; Zugay-Murphy, J.; Reid, J.C.; Tummala, S.; Sharma, S.; Singh, S.B.; Miesel, L.; Lumb, K.J.; Soisson, S.M.
J. Biol. Chem.
288
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Development of novel LpxC inhibitors: chiral-pool synthesis of C-triazolyl glycosides
2013
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Jose, J.; Holl, R.
Tetrahedron
69
9434-9442
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C-Triazolyl beta-D-furanosides as LpxC inhibitors: stereoselective synthesis and biological valuation
2014
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Holl, R.
Tetrahedron
70
6569-6577
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Synthesis and biological evaluation of C-ethynyl furanosides as LpxC inhibitors
2015
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Holl, R.
Tetrahedron
71
956-966
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC Synthesis, antibacterial properties, and docking studies
2019
Kalinin, D.V.; Agoglitta, O.; Van de Vyver, H.; Melesina, J.; Wagner, S.; Riemann, B.; Schaefers, M.; Sippl, W.; Loeffler, B.; Holl, R.
Bioorg. Med. Chem.
27
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Insights into the zinc-dependent deacetylase LpxC biochemical properties and inhibitor design
2016
Kalinin, D.V.; Holl, R.
Curr. Top. Med. Chem.
16
2379-2430
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC
2017
Piizzi, G.; Parker, D.T.; Peng, Y.; Dobler, M.; Patnaik, A.; Wattanasin, S.; Liu, E.; Lenoir, F.; Nunez, J.; Kerrigan, J.; McKenney, D.; Osborne, C.; Yu, D.; Lanieri, L.; Bojkovic, J.; Dzink-Fox, J.; Lilly, M.D.; Sprague, E.R.; Lu, Y.; Wang, H.; Ranjitkar, S.; Xie, L.; Wang, B.; Glick, M.; Hamann, L.G.
J. Med. Chem.
60
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Crystal structure of A. aeolicus LpxC with bound product suggests alternate deacetylation mechanism
2015
Miller, M.; Gao, N.; Ross, P.; Olivier, N.
Proteins
83
1706-1719
Show all BRENDA pathways known for UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine
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