Ligand Cobalamin

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Basic Ligand Information

Molecular Structure
Picture of Cobalamin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C62H90CoN13O14P
Cobalamin
OMAOKVYASDIYQG-DSRCUDDDSA-M
Synonyms:
cob(II)alamin, vitamin B12r

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 ATP + 2 cob(II)alamin + a reduced flavoprotein = 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin = (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cobalamin + 5-methyltetrahydrofolate = methylcobalamin + tetrahydrofolate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin = (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (126 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
class II enzymes
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dependent on
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the smaller one of the two subunits (hcmB) contains a cobalamin cofactor
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Metals and Ions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (62 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (17 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Cobalamin

ChEBI
PubChem
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PubChem