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Ligand octadecyl-lyso-sn-glycero-3-phosphocholine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.67

acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine

487387, 487381

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2.3.1.67

acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine

487387, 487375, 487377, 487388

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2.3.1.67

2 entries

3.1.4.4

1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphatidate + choline

663986

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Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.47

2-acetyl-3-octadecyl-sn-glycero-1-phosphocholine + H2O = 3-octadecyl-sn-glycero-1-phosphocholine + acetate

650057

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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

3.1.1.4

1l8s, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

487375

1495421

1-Alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase

1992

Lee, T.C.; Vallari, D.S.; Snyder, F.

Methods Enzymol.

209

396-401

487377

4030776

Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes

1985

Lee, T.C.

J. Biol. Chem.

260

10952-10955

487381

3196734

Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance

1988

Ninio, E.; Joly, F.; Bessou, G.

Biochim. Biophys. Acta

963

288-294

487387

9219895

Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide

1997

Svetlov, S.I.; Liu, H.; Chao, W.; Olson, M.S.

Biochim. Biophys. Acta

1346

120-130

487388

8951505

Inhibition of lysoPAF acetyltransferase activity by flavonoids

1996

Yanoshita, R.; Chang, H.W.; Son, K.H.; Kudo, I.; Samejina, Y.

Inflamm. Res.

45

546-549

650057

11294621

Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme

2001

Min, J.H.; Wilder, C.; Aoki, J.; Arai, H.; Inoue, K.; Paul, L.; Gelb, M.H.

Biochemistry

40

4539-4549

663986

16024001

Inhibition of phospholipase D activation by CYL-26z in formyl peptide-stimulated neutrophils involves the blockade of RhoA activation

2005

Kuan, Y.H.; Lin, R.H.; Tsao, L.T.; Chen, Y.L.; Tzeng, C.C.; Wang, J.P.

Biochem. Pharmacol.

70

901-910

Links to other databases for octadecyl-lyso-sn-glycero-3-phosphocholine

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Show Links (1 entry)

ChEBI

PubChem

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