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0.001
-
pH 7.5, 75°C, mutant enzyme K53Q
0.007
-
pH 7.5, 75°C, mutant enzyme E51Q
0.025
-
wild-type, pH 7.5, 25°C
0.028
-
N-terminal deletion mutant lacking 26 amino acids, pH 7.5, 25°C
0.03
-
pH 7.5, 25°C, wild-type enzyme
0.038
-
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO
0.04
-
pH 7.0, 25°C, mutant enzyme N90A
0.04
-
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555
0.042
-
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO
0.06
-
pH 7.0, 75°C, mutant enzyme F89A
0.06
-
pH 7.5, 75°C, mutant enzyme K53R
0.06
-
N-terminal deletion mutant lacking 25 amino acids, pH 7.5, 25°C
0.062
-
pH 7.5, 25°C, wild-type enzyme
0.065
-
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555
0.095
-
wild-type, pH 7.5, 25°C
0.11
-
wild-type, pH 7.5, 25°C
0.12
-
mutant enzyme Lys55Ser
0.15
-
pH 7.5, 37°C, wild-type enzyme
0.16
-
mutant G212E, pH 7.5, 25°C
0.16
-
pH 7.0, 25°C, mutant enzyme R54A
0.16
-
pH 7.0, 25°C, wild-type enzyme
0.16
-
pH 7.5, 37°C, mutant enzyme P2S
0.17
-
pH 7.0, 37°C, mutant enzyme N90A
0.19
-
pH 7.0, 37°C, mutant enzyme R54A/N90Q
0.2
-
mutant L236Q, pH 7.5, 25°C
0.23
-
mutant M237T, pH 7.5, 25°C
0.27
-
pH 7.5, 25°C, mutant enzyme P2S/F246S
0.3
-
pH 7.0, 37°C, mutant enzyme N90Q
0.32
-
mutant F246S, pH 7.5, 25°C
0.35
-
pH 7.0, 37°C, mutant enzyme R54A
0.35
-
pH 7.5, 37°C, mutant enzyme F246S
0.36
-
pH 7.5, 37°C, mutant enzyme G212E
0.41
-
pH 7.5, 75°C, mutant enzyme R182A
0.42
-
pH 7.0, 37°C, wild-type enzyme
0.51
-
pH 7.0, 75°C, mutant enzyme R54A/N90Q
0.55
-
pH 7.0, 75°C, mutant enzyme N90A
0.57
-
pH 7.5, 25°C, mutant enzyme P2S/G212E
0.67
-
pH 7.0, 75°C, wild-type enzyme
0.67
-
pH 7.5, 75°C, wild-type enzyme
0.89
-
pH 7.0, 75°C, mutant enzyme N90Q
0.97
-
pH 7.5, 75°C, mutant enzyme E210Q
0.98
-
pH 7.5, 60°C, wild-type enzyme
1.2
-
pH 7.0, 75°C, mutant enzyme R54A
2.1
-
wild-type, pH 7.5, 60°C
3.2
-
genetically engineered monofunctional enzyme form IGPS[1-259]
3.6
-
bifunctional enzyme
4.1
-
at pH 7.5 and 25°C
4.3
-
genetically engineered monofunctional enzyme form IGPS[1-252FAG]
9.3
-
at pH 7.5 and 37°C
11.1
-
at 37°C and pH 8.0
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0.000013
-
pH 7.5, 75°C, mutant enzyme E51Q
0.000023
-
pH 7.0, 37°C, mutant enzyme R54A/N90Q
0.000025
-
wild-type, pH 7.5, 25°C
0.000036
-
pH 7.0, 25°C, mutant enzyme N90A
0.00004
-
pH 7.5, 25°C, wild-type enzyme
0.000044
-
pH 7.0, 75°C, wild-type enzyme
0.000044
-
pH 7.5, 75°C, wild-type enzyme
0.000045
-
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555
0.000045
-
wild-type enzyme
0.000046
-
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO
0.000047
-
genetically engineered monofunctional enzyme form IGPS[1-259]
0.00005
-
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO
0.00005
-
pH 7.5, 37°C, mutant enzyme P2S
0.00005
-
pH 7.5, 37°C, wild-type enzyme
0.00005
-
pH 7.5, 60°C, wild-type enzyme
0.000051
-
pH 7.5, 25°C, wild-type enzyme
0.000074
-
pH 7.0, 25°C, wild-type enzyme
0.000074
-
pH 7.0, 37°C, mutant enzyme N90A
0.000074
-
pH 7.0, 75°C, mutant enzyme R54A
0.000079
-
pH 7.0, 75°C, mutant enzyme N90A
0.000085
-
wild-type, pH 7.5, 25°C
0.000088
-
pH 7.0, 27°C, wild-type enzyme
0.00009
-
wild-type, pH 7.5, 25°C
0.000095
-
pH 7.0, 37°C, mutant enzyme R54A
0.000105
-
wild-type, pH 7.5, 60°C
0.000107
-
pH 7.0, 75°C, mutant enzyme R54A/N90Q
0.000109
-
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555
0.000117
-
pH 7.0, 75°C, mutant enzyme N90Q
0.000132
-
pH 7.0, 37°C, mutant enzyme N90Q
0.000145
-
pH 7.0, 25°C, mutant enzyme R54A
0.00034
-
wild-type enzyme
0.000386
-
pH 7.5, 75°C, mutant enzyme E210Q
0.0004
-
pH 7.5, 37°C, mutant enzyme F246S
0.00042
-
bifunctional enzyme
0.00042
-
pH 7.5, 25°C, mutant enzyme P2S/F246S
0.00069
-
N-terminal deletion mutant lacking 25 amino acids, pH 7.5, 25°C
0.00106
-
pH 7.5, 75°C, mutant enzyme R182A
0.0012
-
pH 7.0, 75°C, mutant enzyme F89A
0.0012
-
wild-type enzyme
0.0013
-
mutant F246S, pH 7.5, 25°C
0.0016
-
at pH 7.5 and 37°C
0.00244
-
pH 7.5, 75°C, mutant enzyme K53R
0.0029
-
mutant M237T, pH 7.5, 25°C
0.0034
-
mutant L236Q, pH 7.5, 25°C
0.0056
-
pH 7.5, 37°C, mutant enzyme G212E
0.0099
-
N-terminal deletion mutant lacking 26 amino acids, pH 7.5, 25°C
0.0099
-
truncated mutant
0.0109
-
pH 7.5, 25°C, mutant enzyme P2S/G212E
0.0113
-
at 37°C and pH 8.0
0.013
-
genetically engineered monofunctional enzyme form IGPS[1-252FAG]
0.0217
-
mutant G212E, pH 7.5, 25°C
1.13
-
increased Km value in the presence of ATB107
1.19
-
H170A site directed mutagenesis
1.42
-
L193A site directed mutagenesis
1.53
-
S64A site directed mutagenesis
1.53
-
V169A site directed mutagenesis
1.81
-
L196A site directed mutagenesis
2.49
-
P63A site directed mutagenesis
2.57
-
N192A site directed mutagenesis
6.63
-
R191A site directed mutagenesis
20.34
-
N189A site directed mutagenesis
21.67
-
E168A site directed mutagenesis
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310-315
The crystal structure of indole-3-glycerol phosphate synthase from hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength
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502-515
Modification of a catalytically important residues of indoleglycerol-phosphate synthase from Escherichia coli
1989
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219-222
2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability
1995
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3
1295-1306
Tryptophan biosynthesis in the marine luminous bacterium Vibrio harveyi
1983
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Purification and characterization of yeast anthranilate phosphoribosyltransferase
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-
Chorismate to tryptophan (Escherichia coli) - anthranilate synthethase, PR transferase; PRA isomerase, InGP synthetase, tryptophan synthetase
1970
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Some physical characteristics of the enzymes of L-tryptophan biosynthesis in higher plants
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Phosphoribosyl anthranilate isomerase catalyzes a reversible amadori reaction
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-
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41
12032-12042
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44
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-
Purification and characterization of Mycobacterium tuberculosis indole-3-glycerol phosphate synthase
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486
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Kinetic mechanism of indole-3-glycerol phosphate synthase
2012
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52
132-142
The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA
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815-821
Improving the catalytic activity of a thermophilic enzyme at low temperatures
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Functional identification of the general acid and base in the dehydration step of indole-3-glycerol phosphate synthase catalysis
2013
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288
26350-26356
Loop-loop interactions govern multiple steps in indole-3-glycerol phosphate synthase catalysis
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302-311
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2011
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67
1054-1064
Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-glycerol phosphate synthase enzymes at their adaptive temperatures
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418
324-329
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31
359-365
Relationship of Catalysis and Active Site Loop Dynamics in the (betaalpha)8 barrel enzyme indole-3-glycerol phosphate synthase
2018
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Biochemistry
57
3265-3277
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