Ligand decylubiquinone

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Basic Ligand Information

Molecular Structure
Picture of decylubiquinone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H30O4
decylubiquinone
VMEGFMNVSYVVOM-UHFFFAOYSA-N
Synonyms:
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone, 6-decyl-ubiquinone, 6-decylubiquinone, coenzyme QD, decyclubiquinone, decyl-ubiquinone, decylubiqinone, dimethoxy-5-methyl-6-decyl-1,4-benzoquinone, n-decylubiquinone
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for decylubiquinone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
thiosulfate + 6-decylubiquinone = tetrathionate + 6-decylubiquinol
-

Substrate in Enzyme-catalyzed Reactions (121 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-glucose + decylubiquinone = D-glucono-1,5-lactone + decylubiquinol
-
show the reaction diagram
sn-glycerol 3-phosphate + decylubiquinone = glycerone phosphate + decylubiquinol
-
show the reaction diagram
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone + reduced coenzyme F420 = 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol + oxidized coenzyme F420
-
show the reaction diagram
NADH + decylubiquinone = NAD+ + decylubiquinol
-
show the reaction diagram
NADH + H+ + n-decylubiquinone = NAD+ + n-decylubiquinol
-
show the reaction diagram
thiosulfate + 6-decylubiquinone = tetrathionate + 6-decylubiquinol
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
decylubiquinol + O2 = decylubiquinone + H2O
-
-
show the reaction diagram
propylene + decylubiquinol + O2 = propylene oxide + decylubiquinone + H2O
-
-
show the reaction diagram
fumarate + reduced decylubiquinone = succinate + decylubiquinone
-
-
show the reaction diagram
nitrate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol = nitrite + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone + H2O
-
-
show the reaction diagram
decylubiquinol + O2 + H+/in = decylubiquinone + H2O + H+/out
-
-
show the reaction diagram
decylubiquinol + H2O2[side 2] + 2 H+[side 2] = decylubiquinone + H2O[side 2] + 2 H+[side 1]
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Enzyme Cofactor/Cosubstrate (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (2 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (141 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (23 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
22°C
wild-type, pH 8.0, 25°C
12
-
wild type enzyme, at pH 8.0 and 25°C
86
-
pH 8.0, 30°C
89
-
pH 8.0, 25°C, cosubstrate L-dihydroorotate, N-terminally truncated protein
1.8
-
mutant Y528W, pH 8.0, 25°C
6.8
-
mutant Y528F, pH 8.0, 25°C
1.2
-
mutant Y528A, pH 8.0, 25°C
0.12
-
mutant R265A, pH 8.0, 25°C
5
-
mutant L531A, pH 8.0, 25°C
8.6
-
mutant I272A, pH 8.0, 25°C
1.8
-
mutant H185A, pH 8.0, 25°C
7.9
-
mutant F227A, pH 8.0, 25°C
3.5
-
mutant F188A, pH 8.0, 25°C
4.3
-
mutant enzyme N302S, at pH 8.0 and 25°C
38
-
recombinant enzyme, pH 7.4, 25°C
59.9
-
-
74.3
-
pH 7.5, 60°C, cytoplasmic mutant enzyme Y383Q/F384K
1.2
-
pH 7.5, 60°C, membrane-bound mutant enzyme M380N
0.62
-
pH 7.5, 60°C, membrane-bound mutant enzyme Y383Q/F384K
0.82
-
pH 7.5, 60°C, membrane-bound wild-type enzyme
0.6
-
at 50°C, pH 6.5
0.38
-

KM Value (87 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 7.6, 30°C
0.011
-
L122stop mutant
0.011
-
22°C
wild-type
0.0048
-
H113Q mutant
0.015
-
W116R mutant
0.018
-
H106Y mutant
0.007
-
H106L/D117V mutant
0.0073
-
F103V mutant
0.01
-
mutant N302S, pH 8.0, 22°C
0.015
-
mutant Y528W, pH 8.0, 25°C
45
-
mutant Y528F, pH 8.0, 25°C
53
-
mutant Y528A, pH 8.0, 25°C
8.8
-
mutant R265A, pH 8.0, 25°C
26
-
mutant enzyme N302S, at pH 8.0 and 25°C
0.015
-
mutant L531A, pH 8.0, 25°C
16
-
mutant I272A, pH 8.0, 25°C
12
-
mutant H185A, pH 8.0, 25°C
34
-
mutant F227A, pH 8.0, 25°C
20
-
mutant enzyme R265A
0.013
-
mutant F188A, pH 8.0, 25°C
20
-
pH 8.0, 22°C, mutant H185A
0.066
-
pH 8.0, 22°C, mutant R265A
0.032
-
pH 8.0, 22°C, wild-type
0.016
-
pH 8.0, 25°C, cosubstrate L-dihydroorotate, N-terminally truncated protein
0.032
-
pH 8.0, 30°C
0.029
-
pH 8.0, 30°C, DELTA1-75 mutant
0.341
-
pH 8.0, 30°C, wild-type
0.112
-
recombinant enzyme
0.0095
-
wild type enzyme, at pH 8.0 and 25°C
0.037
-
wild-type enzyme
0.013
-
wild-type recombinant enzyme
0.011
-
wild-type, pH 8.0, 22°C
0.037
-
wild-type, pH 8.0, 25°C
13
-
expressed in Escherichia coli
0.0095
-
mutant enzyme H185A
0.019
-
expressed in SF21 insect cells
0.0065
-
expressed in Escherichia coli
0.0137
-
DELTA22-37 mutant enzyme
0.0113
-
DELTA2-37 mutant enzyme
0.0118
-
mutant enzyme F188A
0.017
-
DELTA2-21 mutant enzyme
0.0115
-
cosubstrate dihydroorotate
0.014
-
-
0.0084
-
recombinant enzyme, pH 7.4, 25°C
0.0079
-
-
0.00587
-
80°C, pH 6.0
0.0059
-
pH 7.5, 60°C, cytoplasmic mutant enzyme Y383Q/F384K
0.036
-
wild type enzyme, in 250 mM Tris-HCl (pH 8.0), temperature not specified in the publication
0.003
-
20 mM Tris-HCl, pH 8.0, at 22°C
0.0064
-
in 10 mM bis-Tris-HCl, pH 6.5, temperature not specified in the publication
0.002
-
in 50 mM 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol (pH 6.5), temperature not specified in the publication
0.022
-
in 50 mM Bis-Tris (pH 6.5), temperature not specified in the publication
0.0031
-
in 50 mM Bis-Tris (pH 7.0), at 20°C
0.005
-
in 50 mM Tris-HCl, pH 7.4, 40°C
0.00216
-
pH 7.5, 60°C, wild-type enzyme
0.03
-
pH 7.5, 60°C, membrane-bound wild-type enzyme
0.03
-
pH 7.5, 60°C, membrane-bound mutant enzyme Y383Q/F384K
0.033
-
pH 7.5, 60°C, membrane-bound mutant enzyme M380N
0.032
-
wild type enzyme, at pH 7.0 and 23°C
0.00343
-
Km above 0.028 mM, mutant enzyme V300D, in 250 mM Tris-HCl (pH 8.0), temperature not specified in the publication
0.028
-
mutant enzyme H196A, in 250 mM Tris-HCl (pH 8.0), temperature not specified in the publication
0.003
-
mutant enzyme H132A, at pH 7.0 and 23°C
0.0054
-
mutant enzyme H131A, in 250 mM Tris-HCl (pH 8.0), temperature not specified in the publication
0.027
-
mutant enzyme C128S, at pH 7.0 and 23°C
0.00585
-
pH 7.4, temperature not specified in the publication
0.00216
-
mutant enzyme C128A, at pH 7.0 and 23°C
0.00425
-
using 0.1 mM NADH at pH 7.5
0.024
-
-
0.066
-
mutant enzyme H210T
25
-
mutant D228Q (49000 Da subunit)
0.016
-
mutant enzyme R209F
37
-
mutant enzyme V206E
2
3
mutant enzyme Y229H
2
3
wild type enzyme
43
-
mutant F87L (49000 Da subunit)
0.021
-
mutant S416P (49000 Da subunit)
0.017
-
mutant enzyme E228D
40
-
mutant enzyme E216A
43
-
mutant enzyme D213N
34
-
mutant enzyme D213E
33
-
mutant P232G (49000 Da subunit)
0.007
-
mutant R211W (30000 Da subunit)
0.014
-
mutant R231E (49000 Da subunit)
0.029
-
mutant T157I (30000 Da subunit)
0.012
-
mutant S416A (49000 Da subunit)
0.039
-

Ki Value (2 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
mutant enzyme N302S, at pH 8.0 and 25°C
0.000333
-
wild type enzyme, at pH 8.0 and 25°C
0.000174
-

References & Links

Links to other databases for decylubiquinone

ChEBI
PubChem
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PubChem