Ligand lidocaine

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Basic Ligand Information

Molecular Structure
Picture of lidocaine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H22N2O
lidocaine
NNJVILVZKWQKPM-UHFFFAOYSA-N
Synonyms:
lidocain, lidocaine[side 1], lidocaine[side 2], lignocaine
Pathway Source
Pathways

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lidocaine + H2O2 = monoglycinexylidede + glycinexylidide + H2O
show the reaction diagram
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lidocaine + NADPH + O2 = lidocaine-oxide + NADP+
show the reaction diagram
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3'-phosphoadenylylsulfate + lidocaine = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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lidocaine + H2O = 2,6-xylidine + N,N-diethylglycine
show the reaction diagram
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ATP + H2O + lidocaine[side 1] = ADP + phosphate + lidocaine[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + lidocaine[side 1] = ADP + phosphate + lidocaine[side 2]
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strongly inhibits
-
the enzyme inhibition by lignocine may involve voltage-sensitive sodium channels, the enzyme attenuates the induction of MAPK activation by lipopolysaccharides, overview
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inhibition by lidocaine is not competitive with respect to the specific transport and catalytic sites of the enzyme
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.143
-
pH 8.0, 25°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.54
-
-
0.01507
-
at pH 7.4 and 25°C

References & Links

Links to other databases for lidocaine

ChEBI
PubChem
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PubChem