Ligand 2-Methyl-DL-Trp
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Basic Ligand Information
Molecular Structure

C12H14N2O2
2-Methyl-DL-Trp
BXJSOEWOQDVGJW-JTQLQIEISA-N
2-methyltryptophan, D,L-2-methyltryptophan, L-2-methyltryptophan
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan
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Product in Enzyme-catalyzed Reactions (4 results)
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S-adenosyl-L-methionine + D,L-tryptophan = S-adenosyl-L-homocysteine + D,L-2-methyltryptophan
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S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan
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L-serine + 2-methylindole = 2-methyltryptophan + H2O
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L-serine + 2-methylindole = L-2-methyltryptophan + H2O
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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0.02 mM, 30% inhibition
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosyl-methionine:tryptophan 2-methyltransferase
1990
Frenzel, T.; Zhou, P.; Floss, H.G.
Arch. Biochem. Biophys.
278
35-40
3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens Tü 24
1971
Görisch, H.; Lingens, F.
Biochim. Biophys. Acta
242
630-636
Links to other databases for 2-Methyl-DL-Trp