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Ligand 2,6-dioxo-6-phenylhexa-3-enoate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

2wug, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

3v1m, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

3v1n, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

4lye, 3D-view

3.7.1.8

4 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

2wug, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

3v1m, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

3v1n, 3D-view

3.7.1.8

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate

735243, 733047, 733185

4lye, 3D-view

3.7.1.8

4 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (4 entries)

EC NUMBER

ENZYME 3D STRUCTURE

3.7.1.8

2wug, 3D-view

3.7.1.8

3v1m, 3D-view

3.7.1.8

3v1n, 3D-view

3.7.1.8

4lye, 3D-view

3.7.1.8

4 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (20 results)

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Show Turnover Number (20 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.7.1.8

0.13

-

pH 7.0, 25°C, mutant M148P

733185

3.7.1.8

0.86

-

pH 7.0, 25°C, mutant M148R

733185

3.7.1.8

1.5

-

pH 7.0, 25°C, mutant M148S

733185

3.7.1.8

1.5

-

pH 7.0, 25°C, mutant M148Y

733185

3.7.1.8

2.4

-

pH 7.0, 25°C, mutant M148K

733185

3.7.1.8

2.5

-

pH 7.0, 25°C, mutant M148C

733185

3.7.1.8

2.6

-

pH 7.0, 25°C, mutant M148H

733185

3.7.1.8

3.1

-

pH 7.0, 25°C, mutant M148L

733185

3.7.1.8

4.1

-

pH 7.0, 25°C, mutant M148E

733185

3.7.1.8

4.5

-

pH 7.0, 25°C, mutant M148D

733185

3.7.1.8

4.8

-

pH 7.0, 25°C, mutant M148V

733185

3.7.1.8

5.7

-

pH 7.0, 25°C, mutant M148W

733185

3.7.1.8

6.5

-

pH 7.0, 25°C, mutant M148T

733185

3.7.1.8

6.7

-

pH 7.0, 25°C, mutant M148N

733185

3.7.1.8

8

-

pH 7.0, 25°C, mutant M148F

733185

3.7.1.8

8.4

-

pH 7.0, 25°C, mutant M148Q

733185

3.7.1.8

9.4

-

pH 7.0, 25°C, mutant M148G

733185

3.7.1.8

9.5

-

pH 7.0, 25°C, mutant M148I

733185

3.7.1.8

9.6

-

pH 7.0, 25°C, wild-type enzyme

733185

3.7.1.8

9.9

-

pH 7.0, 25°C, mutant M148A

733185

3.7.1.8

20 entries

K_M Value (20 results)

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Show KM Value (20 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.7.1.8

0.00028

-

pH 7.0, 25°C, mutant M148D

733185

3.7.1.8

0.00044

-

pH 7.0, 25°C, mutant M148S

733185

3.7.1.8

0.00047

-

pH 7.0, 25°C, mutant M148W

733185

3.7.1.8

0.00058

-

pH 7.0, 25°C, mutant M148R

733185

3.7.1.8

0.00074

-

pH 7.0, 25°C, mutant M148H

733185

3.7.1.8

0.00075

-

pH 7.0, 25°C, wild-type enzyme

733185

3.7.1.8

0.00078

-

pH 7.0, 25°C, mutant M148I

733185

3.7.1.8

0.00079

-

pH 7.0, 25°C, mutant M148T

733185

3.7.1.8

0.00097

-

pH 7.0, 25°C, mutant M148C

733185

3.7.1.8

0.0012

-

pH 7.0, 25°C, mutant M148K

733185

3.7.1.8

0.0012

-

pH 7.0, 25°C, mutant M148V

733185

3.7.1.8

0.0013

-

pH 7.0, 25°C, mutant M148Q

733185

3.7.1.8

0.0014

-

pH 7.0, 25°C, mutant M148E

733185

3.7.1.8

0.0014

-

pH 7.0, 25°C, mutant M148L

733185

3.7.1.8

0.0014

-

pH 7.0, 25°C, mutant M148N

733185

3.7.1.8

0.0019

-

pH 7.0, 25°C, mutant M148Y

733185

3.7.1.8

0.003

-

pH 7.0, 25°C, mutant M148P

733185

3.7.1.8

0.0042

-

pH 7.0, 25°C, mutant M148F

733185

3.7.1.8

0.0049

-

pH 7.0, 25°C, mutant M148G

733185

3.7.1.8

0.0051

-

pH 7.0, 25°C, mutant M148A

733185

3.7.1.8

20 entries

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

733047

-

C-C hydrolases for biocatalysis

2013

Siirola, E.; Frank, A.; Grogan, G.; Kroutil, W.

Adv. Synth. Catal.

355

1677-1691

733185

23494625

The key role of a non-active-site residue Met148 on the catalytic efficiency of meta-cleavage product hydrolase BphD

2013

Zhou, H.; Qu, Y.; Kong, C.; Shen, E.; Wang, J.; Zhang, X.; Ma, Q.; Zhou, J.

Appl. Microbiol. Biotechnol.

97

10399-10411

735243

-

Insight into the catalytic mechanism of meta-cleavage product hydrolase BphD: a quantum mechanics/molecular mechanics study

2015

Li, Y.; Zhang, R.; Du, L.; Zhang, Q.; Wang, W.

RSC Adv.

5

66591-66597

Links to other databases for 2,6-dioxo-6-phenylhexa-3-enoate

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Show Links (1 entry)

ChEBI

PubChem

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