Ligand 6-thioguanosine

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Basic Ligand Information

Molecular Structure
Picture of 6-thioguanosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H13N5O4S
6-thioguanosine
OTDJAMXESTUWLO-UUOKFMHZSA-N
Synonyms:
6-mercaptoguanosine, 6-thioguanine-riboside, 6-thioguanine ribonucleoside

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + 6-thioguanine-riboside = S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside
show the reaction diagram
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6-mercaptoguanosine + phosphate = alpha-D-ribose 1-phosphate + 6-mercaptoguanine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-thioguanine + alpha-D-ribose 1-phosphate = 6-thioguanine ribonucleoside + phosphate
show the reaction diagram
-
-
thymidine + 6-mercaptoguanine = thymine + 6-mercaptoguanosine
show the reaction diagram
-
-
thio-GMP + H2o = 6-thioguanosine + phosphate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
expression of isoform IMPDH2 increases modestly in response to 6-thioguanosine exposure. However, the basal enzyme activity decreases when the cells are exposed to a proliferation-blocking 6-thioguanosine concentration
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.167
-
-

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for 6-thioguanosine

ChEBI
PubChem
ChEBI
PubChem