print visible entries

print all entries

Ligand 1,2-diheptanoyl-sn-glycero-3-phosphocholine

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.4

1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O = 1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate

133892, 133926, 133927, 133886

-

3.1.1.4

1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O = 1-heptanoyl-sn-glycero-3-phosphocholine + heptanoate

679198

-

3.1.1.4

2 entries

3.1.4.3

1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-diheptanoyl-sn-glycerol + phosphocholine

749975

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.300

substitution of the detergent 1,2-diheptanoyl-sn-glycero-3-phosphocholine for Tween-20 results in complete inactivation of the enzyme

686690

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

top print hide

Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.1.4

3.86

-

pH 8.5, 37°C, recombinant AtsPLA2-alpha

679198

3.1.1.4

4.6

-

monodispersed substrate

133886

3.1.1.4

43.3

-

micellar substrate

133886

3.1.1.4

3 entries

3.1.4.3

8.5

-

at pH 6.0 and 37°C

749975

K_M Value (7 results)

top print hide

Show KM Value (7 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.4

1.12

-

micellar substrate

133886

3.1.1.4

1.4

-

micellar substrate, enzyme saturated with Ca2+

133886

3.1.1.4

3

-

-

133892

3.1.1.4

3.6

-

-

133892

3.1.1.4

3.92

-

pH 8.5, 37°C, recombinant AtsPLA2-alpha

679198

3.1.1.4

5.13

-

monodispersed substrate

133886

3.1.1.4

6 entries

3.1.4.3

8.5

-

at pH 6.0 and 37°C

749975

References & Links

Literature References (7)

top print hide

Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

133886

8454568

Hydrolysis of micellar diheptanoylphosphatidylcholine catalyzed by bovine pancreatic phospholipase A2: Kinetic characterization of group I and II enzymes

1993

Hada, S.; Fujii, S.; Inoue, S.; Ikeda, K.; Teshima, K.

J. Biochem.

113

13-18

133892

1730245

Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli

1992

Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.

Eur. J. Biochem.

203

89-98

133926

4856505

Histidine at the active site of phospholipase A2

1974

Volwerk, J.J.; Pieterson, W.A.; de Haas, G.H.

Biochemistry

13

1446-1454

133927

4819758

Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2

1974

Pieterson, W.A.; Vidal, J.C.; Volwerk, J.J.; de Haas, G.H.

Biochemistry

13

1455-1460

679198

17692835

Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference

2007

Mansfeld, J.; Ulbrich-Hofmann, R.

Chem. Phys. Lipids

150

156-166

686690

18039331

Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity

2008

Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kedishvili, N.Y.

FEBS J.

275

138-147

749975

26976751

Recombinant broad-range phospholipase C from Listeria monocytogenes exhibits optimal activity at acidic pH

2016

Huang, Q.; Gershenson, A.; Roberts, M.F.

Biochim. Biophys. Acta

1864

697-705

Links to other databases for 1,2-diheptanoyl-sn-glycero-3-phosphocholine

top print hide

Show Links (1 entry)

ChEBI

PubChem

-