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Ligand cobyrinate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for cobyrinate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.5.9

ATP + cobyrinic acid + L-glutamine + H2O = ADP + phosphate + cobyrinic acid a,c-diamide + L-glutamate

644524

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.99.60

cobalt-precorrin-8 = cobyrinate

0

-

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.17

cob(I)yric acid + ATP = 5'-deoxy-5'-adenosyl-cob(I)yric acid + polyphosphate

636868

-

6.3.5.11

2 ATP + cobyrinate + 2 ammonia + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide

661083, 644524

-

6.3.5.11

2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate

644524, 661083

-

6.3.5.9

ATP + cobyrinic acid + ammonia + H2O = ADP + phosphate + ?

644524

-

6.3.5.9

ATP + cobyrinic acid + L-glutamine + H2O = ADP + phosphate + cobyrinic acid a,c-diamide + L-glutamate

485086, 644524

-

6.3.5.9

cobyrinic acid + ATP + glutamine = cobyrinic acid a,c-diamide + ADP + phosphate + glutamate

661083

-

6.3.5.9

cobyrinic acid + ATP + NH4+ = cobyrinic acid a,c-diamide + ADP + phosphate

661083

-

6.3.5.11

2 entries

6.3.5.9

4 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.4.99.60

cobalt-precorrin-8 = cobyrinate

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.3.5.11

0.16

-

pH 7.7, 30°C

661083

6.3.5.9

0.16

-

pH 7.7, wild-type enzyme

661083

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.5.11

0.00074

-

pH 7.7, 30°C

661083

6.3.5.9

0.00074

-

pH 7.7, wild-type enzyme

661083

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

485086

2211520

Nucleotide sequence of a Pseudomonas denitrificans 5.4-kilobase DNA fragment containing five cob genes and identification of structural genes encoding S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase and cobyrinic acid a,c-diamide synthase

1990

Crouzet, J.; Cauchois, L.; Blanche, F.; Debussche, L.; Thibaut, D.; Rouyez, M.C.; Rigault, S.; Mayaux, J.F.; Cameron, B.

J. Bacteriol.

172

5968-5979

636868

1917862

Purification and partial characterization of Cob(I)alamin adenosyltransferase from Pseudomonas denitrificans

1991

Debussche, L.; Couder, M.; Thibaut, D.; Cameron, B.; Crouzet, J.; Blanche, F.

J. Bacteriol.

173

6300-6302

644524

2172209

Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans

1990

Debussche, L.; Thibaut, D.; Cameron, B.; Crouzet, J.; Blanche, F.

J. Bacteriol.

172

6239-6244

661083

15311923

Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2

2004

Fresquet, V.; Williams, L.; Raushel, F.M.

Biochemistry

43

10619-10627

Links to other databases for cobyrinate

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Show Links (1 entry)

ChEBI

PubChem