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Ligand Val-Phe Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 4 H2 0 N2 O3
Val-Phe
GJNDXQBALKCYSZ-RYUDHWBXSA-N
L-Val-L-Phe, Val-Phe-OH, VF
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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L-Val-L-Phe + H2O = L-Val + L-Phe
-
Product in Enzyme-catalyzed Reactions (1 result)
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Abz-YNPFVFT-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O = Abz-YNPF + VF + T-Q-N-[2,4-dinitrophenyl]-ethylenediamine
-
Inhibitor in Enzyme-catalyzed Reactions (4 results)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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Ki Value (2 results)
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0.021
-
37°C, pH 7.2, wild-type enzyme
IC50 Value (2 results)
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0.0092
-
pH and temperature not specified in the publication
0.051
-
in 0.1 mM sodium borate buffer, 0.3 mM NaCl, pH 8.3, at 37°C
References & Links Literature References (5)
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Purification and characterization of Aeromonas caviae aminopeptidase possessing dibittering activity.
1997
Izawa, N.; Ishikawa, S.; Tanokura, T.; Ohta, K.; Hayashi, K.
J. Agric. Food Chem.
45
4897-4902
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors
2000
Ganellin, C.R.; Bishop, P.B.; Bambal, R.B.; Chan, S.M.; Law, J.K.; Marabout, B.; Luthra, P.M.; Moore, A.N.; Peschard, O.; Bourgeat, P.; Rose, C.; Vargas, F.; Schwartz, J.C.
J. Med. Chem.
43
664-674
A three-dimensional model of the neprilysin 2 active site based on the X-ray structure of neprilysin. Identification of residues involved in substrate hydrolysis and inhibitor binding of neprilysin 2
2004
Voisin, S.; Rognan, D.; Gros, C.; Ouimet, T.
J. Biol. Chem.
279
46172-46181
Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides
2008
Pentzien, A.K.; Meisel, H.
Z. Naturforsch. C
63
451-459
Plant food-derived angiotensin I converting enzyme inhibitory peptides
2009
Guang, C.; Phillips, R.D.
J. Agric. Food Chem.
57
5113-5120
Links to other databases for Val-Phe
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