Ligand pentanoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of pentanoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H44N7O17P3S
pentanoyl-CoA
RXUATCUKICAIOA-ZMHDXICWSA-N
Synonyms:
n-pentanoyl-CoA, n-valeryl-CoA, pentanoyl-coenzyme A, valeryl-CoA, valeryl-coenzyme A, valeryl CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pentanoyl-CoA + acceptor = pent-2-enoyl-CoA + reduced acceptor
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-pentenoyl-CoA + reduced electron transfer flavoprotein = pentanoyl-CoA + electron transfer protein
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pentanoyl-CoA + acceptor = ? + reduced acceptor
show the reaction diagram
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pentanoyl-CoA + acceptor = 2-pentenoyl-CoA + reduced acceptor
show the reaction diagram
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valeryl-CoA + malonyl-CoA = 6-butyl triacetic acid lactone + CoA
show the reaction diagram
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valeryl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-heptanoyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
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n-valeryl-CoA + carnitine = n-valerylcarnitine + CoASH
show the reaction diagram
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valeryl-CoA + 13-hydroxylupanine = CoA + 13-valeryloxylupanine
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pentanoyl-CoA + glyoxylate + H2O = 3-propylmalate + CoA
show the reaction diagram
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2-oxo-3-methylbutanoate + valeryl-CoA + H2O = 2-hydroxy-2-isopropyl-3-propylsuccinic acid + CoA
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valeryl-CoA + propanoate = ?
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valeryl-CoA = pentanoate + CoA
show the reaction diagram
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valeryl-CoA + H2O = valerate + CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
valeraldehyde + coenzyme A + NADP+ = n-valeryl-CoA + NADPH + H+
show the reaction diagram
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pentaldehyde + CoA + NAD+ = pentanoyl-CoA + NADH + H+
show the reaction diagram
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2-ketocaproate + CoA + oxidized ferredoxin = pentanoyl-CoA + CO2 + reduced ferredoxin
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CoA + 3-oxoheptanoyl-CoA = acetyl-CoA + pentanoyl-CoA
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n-valerylcarnitine + CoASH = n-valeryl-CoA + carnitine
show the reaction diagram
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acetyl-CoA + valerate = acetate + valeryl-CoA
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pentanoate + acetoacetyl-CoA = pentanoyl-CoA + acetoacetate
show the reaction diagram
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isovaleryl-CoA = pentanoyl-CoA
show the reaction diagram
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ATP + pentanoate + CoA = AMP + diphosphate + pentanoyl-CoA
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 50% inhibition
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competitive inhibition
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weak
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.267
-
using recombinant enzyme, electron acceptor: electron-transferring flavoprotein

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.024
-
-
0.071
-
-
0.9
-
-
0.025
-
-
0.007
0.026
estimated from rates at lower and higher substrate concentration

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.6
-
pH 6.0, 30°C
0.72
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recombinant enzyme, pH 8.0, 30°C

References & Links

Links to other databases for pentanoyl-CoA

ChEBI
PubChem
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PubChem