Ligand 1,3-dicyclohexylcarbodiimide

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Basic Ligand Information

Molecular Structure
Picture of 1,3-dicyclohexylcarbodiimide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C13H22N2
1,3-dicyclohexylcarbodiimide
QOSSAOTZNIDXMA-UHFFFAOYSA-N
Synonyms:
1,3-dicyclohexyl-1,3-diazapropa-1,2-diene, 1,3-dicyclohexyl carbodiimide, DCCD, dicyclohexylcarbodi-imide, Dicyclohexylcarbodiimide, dicyclohexyl carbodiimide, dicylcohexylcarbodiimid, N',N'-dicyclohexylcarbodiimide, N,N'-dicyclohexyl-carbodiimide, N, N'-Dicyclohexylcarbodiimide, N,N'-dicyclohexylcarbodiimide, N,N'-Dicylclohexylcarbodiimide, N,N-Dicyclohexylcarbodiimide, N,N’-dicyclohexylcarbodiimide

Show all pahtways known for Show all pathways known for 1,3-dicyclohexylcarbodiimide

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + N',N'-dicyclohexylcarbodiimide = NAD+ + ?
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM increases ATPase activity by 20%
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Inhibitor in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 mM, 79% inhibition of wild-type enzyme after 4 h at room temperature, 74% inhibition of mutant enzyme K46A, 77% inhibition of mutant enzyme E51A, 71% inhibition of mutant enzyme D79A, 76% inhibitiuon of mutant enzyme D79N, 50% inhibition of mutant enzyme E81A, 30% inhibition of mutant enzyme E81Q
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76% inhibition
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nearly complete inhibition at 10 mM
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0.01 mM, complete inhibition
-
inhibitor binds to Asp140 and Glu222 of the enzyme, inactivation with pseudo-first-order kinetics, inactivation is prevented by a competitive inhibitor, tyrostatin
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DCCD, slightly inhibited
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0.01 mM, 76% residual activity
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0.1 mM, 43% inhibition
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10 mM, 82% inhibition
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0.05 mM, complete inactivation after 30 min in MES, pH 6.0
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Metals and Ions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.3 mM, 59% inhibition
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Enzyme Kinetic Parameters

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.25
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90% inhibition, IC50: 0.25 mM

References & Links

Links to other databases for 1,3-dicyclohexylcarbodiimide

ChEBI
PubChem
ChEBI
PubChem