Ligand dTDP-alpha-D-glucose

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Basic Ligand Information

Molecular Structure
Picture of dTDP-alpha-D-glucose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H26N2O16P2
dTDP-alpha-D-glucose
YSYKRGRSMLTJNL-URARBOGNSA-N
Synonyms:
5-(thymidine-5'-diphosphoryl)-D-glucose, alpha-TDP-glucose, dTDP-D-glucose, dTDP-glucose, dTDPglucose, TDP-alpha-D-glucose, TDP-D-glucose, TDP-glucose, TDPglucose, TDP glucose, TTP-glucose

Show all pahtways known for Show all pathways known for dTDP-alpha-D-glucose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TDP-D-glucose + 2 NADP+ + H2O = TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
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TDP-glucose + H2O = TMP + D-glucose-1-phosphate
show the reaction diagram
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dTDP-D-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TTP + alpha-D-glucose 1-phosphate = diphosphate + TDP-D-glucose
show the reaction diagram
-
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dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (68 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dTDP-alpha-D-glucose + NADP+ = ?
show the reaction diagram
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TDP-D-glucose + 2 NADP+ + H2O = TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
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TDP-glucose + acceptor = TDT-3-dehydro-D-glucose + reduced acceptor
show the reaction diagram
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dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1
show the reaction diagram
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dTDP-alpha-D-glucose + sinapic acid = dTDP + 1-O-sinapoyl-beta-D-glucose
show the reaction diagram
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TDP-glucose + D-fructose = TDP + sucrose
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TDP-glucose + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R = TDP + ?
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TDP-glucose + hydroquinone = TDP + hydroquinone-O-beta-D-glucopyranoside
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TDP-glucose + a flavonol 3-O-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside
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TDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucoside = TDP + a flavonol 3-O-beta-D-glucosyl-(1-2)-beta-D-glucosyl-(1-2)-beta-D-glucoside
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dTDP-glucose + (1,4-alpha-D-glucosyl)n = dTDP + (1,4-alpha-D-glucosyl)n+1
show the reaction diagram
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TDP-glucose + 3-phospho-D-glycerate = TDP + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
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dTDP-D-glucose + 2-deoxystreptamine = ?
show the reaction diagram
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TDP-alpha-D-glucose + validoxylamine A = TDP + validamycin A
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dTDP-glucose + p-nitrophenol = dTDP + p-nitrophenyl beta-D-glucoside
show the reaction diagram
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dTDP-glucose + poly(glycerophosphate) = dTDP + alpha-D-glucosyl-poly(glycerol phosphate)
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TDP-glucose + D-galactosylhydroxylysine = TDP + 1,2-D-glucosyl-D-galactosylhydroxylysine
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TDP-glucose + an arylamine = TDP + an N-D-glucosylarylamine
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TDP-glucose + N-acylsphingosine = TDP + D-glucosyl-N-acylsphingosine
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TDP-glucose + luteolin = TDP + 7-O-beta-D-glucosylluteolin
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dTDP-glucose + quercetin = dTDP + quercetin 3-O-beta-D-glucoside
show the reaction diagram
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TDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + TDP-galactose
show the reaction diagram
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dTDP-glucose + phosphate = dTDP + D-glucose 1-phosphate
show the reaction diagram
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diphosphate + TDP-glucose = TTP + alpha-D-glucose 1-phosphate
show the reaction diagram
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TDP-glucose + H2O = ?
show the reaction diagram
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TDP-D-glucose = TDP-D-galactose
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, as effective as UDPglucose, in concentrations exceeding UDPxylose
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activates 4.6% at 5 mM
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive against UDP-N-acetyl-D-glucosamine
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weak
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competitive, 70% inhibition
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reductive inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (41 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (56 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.37
-
at pH 7.5, temperature not specified in the publication
4
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80C, pH 5.0
2.9
-
-
1.1
-
-
2
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37C, pH 5.5
0.029
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soluble enzyme
0.26
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reaction with apigenin
1.8
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pH 4.5, 37C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1
-
-

References & Links

Links to other databases for dTDP-alpha-D-glucose

ChEBI
PubChem
ChEBI
PubChem