Ligand DL-propargylglycine

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Basic Ligand Information

Molecular Structure
Picture of DL-propargylglycine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H7NO2
DL-propargylglycine
PADQINQHPQKXNL-UHFFFAOYSA-N
Synonyms:
(DL)-propargylglycine, DL-C-propagylglycine, DL-C-propargylglycine, L-Propargylglycine, propargylglycine, propargyl glycine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-propargylglycine + phenazine ethosulfate + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloridehydrate + NAD+ = ? + NADH
show the reaction diagram
-
L-propargylglycine = (E)-pent-2-ene-4-ynoate + NH3
show the reaction diagram
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ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-propargylglycine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-propargylglycine
show the reaction diagram
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ATP + UDP-N-acetylmuramate + DL-propargylglycine = ADP + phosphate + UDP-N-acetylmuramoyl-DL-propargylglycine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(E)-pent-2-ene-4-ynoate + NH3 = L-propargylglycine
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
irreversible inhibition in a dose- and time-dependent manner
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (18 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.37
-
pH 8.8, 30°C
20
-
-

KM Value (18 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
16
-
pH 8.8, 30°C
1.1
-
-

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
-
0.035
-
-

IC50 Value (9 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for DL-propargylglycine

ChEBI
PubChem
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PubChem