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Ligand piperidine

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.145

(E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine

486332

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.145

(E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine

486332

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.7.1.10

N-hydroxypiperidine + NADH = piperidine + NAD+ + H2O

394435

-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.22

10 mM, 55% inhibition

391948

-

2.5.1.18

about 15% inhibition at 0.1 mM

759335

-

3.4.14.10

-

665981

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.145

10

-

-

486332

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.22

1.2

-

-

391948

3.4.14.10

0.012

-

-

665981

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

391948

8239662

Purification and characterization of amine oxidase from soybean seedlings

1993

Vianello, F.; Di Paolo, M.L.; Stevanato, R.; Gasparini, R.; Rigo, A.

Arch. Biochem. Biophys.

307

35-39

394435

4147171

Reduced pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes

1973

Kadlubar, F.F.; Mckee, E.M.; Ziegler, D.M.

Arch. Biochem. Biophys.

156

46-57

486332

-

The biosynthesis of piperine in Piper nigrum

1990

Geisler, J.G.; Gross, G.G.

Phytochemistry

29

489-492

665981

16279793

Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors

2005

Ganellin, C.R.; Bishop, P.B.; Bambal, R.B.; Chan, S.M.; Leblond, B.; Moore, A.N.; Zhao, L.; Bourgeat, P.; Rose, C.; Vargas, F.; Schwartz, J.C.

J. Med. Chem.

48

7333-7342

759335

29578047

Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification

2018

Gonzalez, D.; Fraichard, S.; Grassein, P.; Delarue, P.; Senet, P.; Nicolai, A.; Chavanne, E.; Mucher, E.; Artur, Y.; Ferveur, J.F.; Heydel, J.M.; Briand, L.; Neiers, F.

Insect Biochem. Mol. Biol.

95

33-43

759335

29578047

Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification

2018

Gonzalez, D.; Fraichard, S.; Grassein, P.; Delarue, P.; Senet, P.; Nicolai, A.; Chavanne, E.; Mucher, E.; Artur, Y.; Ferveur, J.F.; Heydel, J.M.; Briand, L.; Neiers, F.

Insect Biochem. Mol. Biol.

95

33-43

759335

2 entries

Links to other databases for piperidine

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Show Links (1 entry)