Ligand gamma-L-Glu-L-Ser
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Basic Ligand Information
Molecular Structure
C8H14N2O6
gamma-L-Glu-L-Ser
SQBNIUOYNOKDTI-WHFBIAKZSA-N
(gamma-L-glutamyl)-L-serine, 5-L-glutamyl-L-Ser, 5-L-glutamyl-Ser, gamma-L-Glu-L-serine, L-gamma-Glu-L-Ser
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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(gamma-L-glutamyl)-L-serine = 5-oxoproline + L-serine
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ATP + L-gamma-Glu-L-Ser + Gly = ADP + phosphate + L-gamma-Glu-L-Ser-Gly
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Product in Enzyme-catalyzed Reactions (4 results)
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5-L-glutamyl-4-nitroanilide + L-Ser = 4-nitroaniline + 5-L-glutamyl-L-Ser
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5-L-glutamyl-4-nitroanilide + Ser = 4-nitroaniline + 5-L-glutamyl-Ser
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ATP + L-Glu + L-Ser = ADP + phosphate + gamma-L-Glu-L-Ser
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ATP + L-Glu + L-serine = ADP + phosphate + gamma-L-Glu-L-serine
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Enzyme Kinetic Parameters
References & Links
Literature References (4)
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Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites
1979
Oppenheimer, L.; Wellner, V.P.; Griffith, O.W.; Meister.A.
J. Biol. Chem.
254
5184-5190
The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase
1999
Griffith, O.W.; Mulcahy, R.T.
Adv. Enzymol. Relat. Areas Mol. Biol.
73
209-267
Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding
2002
Kelly, B.S.; Antholine, W.E.; Griffith, O.W.
J. Biol. Chem.
277
50-58
A fluorogenic probe for gamma-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction
2013
Yoshiya, T.; Tsuda, S.; Mochizuki, M.; Hidaka, K.; Tsuda, Y.; Kiso, Y.; Kageyama, S.; Ii, H.; Yoshiki, T.; Nishiuchi, Y.
ChemBioChem
14
2110-2113
Links to other databases for gamma-L-Glu-L-Ser
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