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0.26
-
pH 7.5, 30°C, ZnCo-loaded enzyme
0.65
-
mutant enzyme E134D at pH 7.5
0.73
-
pH 7.5, 30°C, Zn-loaded enzyme
0.73
-
pH 7.5, 30°C, ZnZn-loaded enzyme
0.73
-
wild type enzyme at pH 7.5
0.74
-
pH 7.5, 30°C, CoZn-loaded enzyme
0.8
-
pH 7.5, 25°C, recombinant wild-type enzyme
0.99
-
pH 7.5, 30°C, Co-loaded enzyme
0.99
-
pH 7.5, 30°C, CoCo-loaded enzyme
1.2
-
pH 7.5, 25°C, recombinant enzyme
1.3
-
25°C, pH 7.6, in the presence of Zn2+
1.3
-
in the presence of Zn2+
1.5
-
37°C, pH 8.1, in the presence of Co2+
1.6
-
25°C, pH 7.6, in the presence of Co2+
1.6
-
in the presence of Co2+
2.1
-
pH 7.5, 25°C, recombinant mutant T325A
3
-
pH 7.5, 25°C, recombinant mutant T325S
4.7
-
in the presence of Co2+
730
-
pH not specified in the publication, temperature not specified in the publication
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-
N-succinyl-L-alpha, epsilon-diaminopimelic acid deacylase
1960
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Hydrolysis of N-succinyl-L,L-diaminopimelic acid by Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism
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Structure/function studies on enzymes in the diaminopimelate pathway of bacterial cell wall biosynthesis
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N-succinyl-L-diaminopimelic-glutamic transaminase
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Substrate specificity, metal binding properties, and spectroscopic characterization of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae
2003
Bienvenue, D.L.; Gilner, D.M.; Davis, R.S.; Bennett, B.; Holz, R.C.
Biochemistry
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Identification and characterization of the last two unknown genes, dapC and dapF, in the succinylase branch of the L-lysine biosynthesis of Corynebacterium glutamicum
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Kinetic and spectroscopic characterization of the E134A- and E134D-altered dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae
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Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity
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Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase
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Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum
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Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of succinyl-diaminopimelate desuccinylase (Rv1202, DapE) from Mycobacterium tuberculosis
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Acta Crystallogr. Sect. F
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Mono-N-acyl-2,6-diaminopimelic acid derivatives: analysis by electromigration and spectroscopic methods and examination of enzyme inhibitory activity
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The structural and energetic aspects of substrate binding and the mechanism of action of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) investigated using a hybrid QM/MM method
2014
Dutta, D.; Mishra, S.
Phys. Chem. Chem. Phys.
16
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The dimerization domain in DapE enzymes is required for catalysis
2014
Nocek, B.; Starus, A.; Makowska-Grzyska, M.; Gutierrez, B.; Sanchez, S.; Jedrzejczak, R.; Mack, J.C.; Olsen, K.W.; Joachimiak, A.; Holz, R.C.
PLoS ONE
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Identification of a histidine metal ligand in the argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli
2013
McGregor, W.C.; Gillner, D.M.; Swierczek, S.I.; Liu, D.; Holz, R.C.
SpringerPlus
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Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent microorganisms
2014
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J. Biol. Chem.
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Inhibition of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Neisseria meningitidis by L-captopril
2015
Starus, A.; Nocek, B.; Bennett, B.; Larrabee, J.A.; Shaw, D.L.; Sae-Lee, W.; Russo, M.T.; Gillner, D.M.; Makowska-Grzyska, M.; Joachimiak, A.; Holz, R.C.
Biochemistry
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Loss of catalytic activity in the E134D, H67A, and H349A mutants of DapE mechanistic analysis with QM/MM investigation
2016
Dutta, D.; Mishra, S.
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Practical spectrophotometric assay for the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase, a potential antibiotic target
2018
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Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase
2016
Usha, V.; Lloyd, A.J.; Roper, D.I.; Dowson, C.G.; Kozlov, G.; Gehring, K.; Chauhan, S.; Imam, H.T.; Blindauer, C.A.; Besra, G.S.
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Show all BRENDA pathways known for N-succinyl-LL-2,6-diaminoheptanedioate
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