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Ligand Demethylmacrocin Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C4 4 H7 3 NO1 7
Demethylmacrocin
ALZAOGATQMXJKX-PLJQDSASSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
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Substrate in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + 2'''-O-demethyltylosin
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S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin
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Product in Enzyme-catalyzed Reactions (1 result)
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dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
KM Value (1 result)
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Ki Value (1 result)
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References & Links Literature References (3)
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Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae
1988
Bauer, N.J.; Kreuzman, A.J.; Dotzlaf, J.E.; Yeh, W.K.
J. Biol. Chem.
263
15619-15625
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism
1988
Kreuzman, A.J.; Turner, J.R.; Yeh, W.K.
J. Biol. Chem.
263
15626-15633
Characterization of the two methylation steps involved in the biosynthesis of mycinose in tylosin
2016
Kim, E.; Song, M.; Kim, M.; Beom, J.; Lee, E.; Kim, D.; Nam, S.; Yoon, Y.
J. Nat. Prod.
79
2014-2021
Links to other databases for Demethylmacrocin