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Ligand (R)-1-aminopropan-2-ol

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for (R)-1-aminopropan-2-ol

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.1.10

ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

644461

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.90

adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol

0, 648210

-

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.103

(R)-(-)-1-amino-2-propanol + NAD+ = ?

762551

-

1.1.1.6

R-1-amino-2-propanol + NAD+ = ?

636298

-

1.1.1.75

D-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+

287302, 287300

-

2.7.1.82

ATP + (R)-1-aminopropan-2-ol = ADP + (R)-1-aminopropyl 2-phosphate

685011

-

6.3.1.10

ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

644461

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.1.90

adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol

0, 648210

-

3.5.1.90

adenosylpseudocobalamine + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol

0

-

3.5.1.90

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.75

competitive

287299, 287304

-

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (2 entries)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.1.1

6sdj, 3D-view

5.4.99.1

1id8, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.103

0.0085

-

25°C, pH 10, mutant enzyme G114A

762551

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.103

0.36

-

25°C, pH 10, mutant enzyme G114A

762551

1.1.1.6

4.4

-

pH 8.8, 25°C

636298

1.1.1.75

54

-

-

287302

1.1.1.75

110

-

-

287300

1.1.1.75

2 entries

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

287299

5340733

Microbial metabolism of amino ketones. L-1-aminopropan-2-ol dehydrogenase and L-threonine dehydrgenase in Escerichia coli

1967

Turner, J.M.

Biochem. J.

104

112-121

287300

4303396

Aminopropanol dehydrogenase activity in rat-liver preparations

1968

Cox, N.; Turner, J.M.; Willetts, A.J.

Biochim. Biophys. Acta

170

438-439

287302

4334917

Threonine metabolism in a strain of Bacillus subtilis enzymic oxidation of 1-aminopropan-2-ol and aminoacetone

1971

Willetts, A.J.; Turner, J.M.

Biochim. Biophys. Acta

252

98-104

287304

5729604

Purification and properties of l-1-aminopropan-2-ol. NAD oxidoreductase from a pseudomonad grown on DL-1-aminopropan-2-ol

1968

Pickard, M.A.; Higgins, I.J.; Turner, J.M.

J. Gen. Microbiol.

54

115-126

636298

7981227

Isotopic analysis of the reaction catalyzed by glycerol dehydrogenase

1994

Leichus, B.N.; Blanchard, J.S.

Biochemistry

33

14642-14649

644461

11939774

Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica

2002

Cheong, C.G.; Bauer, C.B.; Brushaber, K.R.; Escalante-Semerena, J.C.; Rayment, I.

Biochemistry

41

4798-4808

648210

14990804

CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea

2004

Woodson, J.D.; Escalante-Semerena, J.C.

Proc. Natl. Acad. Sci. USA

101

3591-3596

685011

18489261

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

2008

Gibellini, F.; Hunter, W.N.; Smith, T.K.

Biochem. J.

415

135-144

762551

31457655

Systematic functional analysis of active-site residues in l-threonine dehydrogenase from Thermoplasma volcanium

2017

Desjardins, M.; Mak, W.S.; OBrien, T.E.; Carlin, D.A.; Tantillo, D.J.; Siegel, J.B.

ACS Omega

2

3308-3314

Links to other databases for (R)-1-aminopropan-2-ol

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Show Links (1 entry)

ChEBI

PubChem