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BRENDA support

Ligand vitexin

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Basic Ligand Information

Molecular Structure
Picture of vitexin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C21H20O10
vitexin
SGEWCQFRYRRZDC-VPRICQMDSA-N

Related pathways

Pathway Source
Pathways
MetaCyc
flavonoid di-C-glucosylation, naringenin C-glucosylation, vitexin and derivatives biosynthesis

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-glucose + vitexin = UDP + vitexin 2''-O-beta-D-glucoside
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-glucose + vitexin = UDP + vitexin 2''-O-beta-D-glucoside
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-
27.01% inhibition at 0.2 mM
-
inhibition of the ACE2 enzyme
-
interacts with enzyme residues Leu83, Ala84, His130, Pro140, Ala139, Met138, Ala, 136, Leu137, Thr143, Tyr142, Val117, His120, and Ile141, binding structure analysis, and modelling, overview
-
interacts with enzyme residues Leu193, Tyr219, Ala161, Asn218, His207, Glu198, Gly158, Pro217, His201, and Val194, binding structure analysis, and modelling, overview
-
interacts with enzyme residues Gly186, Pro246, His236, Met247, Tyr248, Val223, and Leu188, binding structure analysis, and modeling, overview
-

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.01
-
-

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0389
-
pH 7.0 and 37°C
0.24
-
pH 6, 25°C

References & Links

Links to other databases for vitexin

EXTERNAL LINKS