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Ligand valproyl-CoA

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.137

valproyl-CoA + L-carnitine = L-valproyl-L-carnitine + CoA

486300

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.137

valproyl-L-carnitine + CoA = valproyl-CoA + L-carnitine

-

-

6.2.1.2

ATP + valproate + CoA = ADP + diphosphate + valproyl-CoA

-

-

6.2.1.2

ATP + valproic acid + CoA = AMP + diphosphate + valproyl-CoA

650831, -

-

6.2.1.2

2 entries

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.8.4

competitive

724826

-

1.8.1.4

competitive inhibitor, 0.5-1.0 mM inhibit DLDH activity

691036

-

6.2.1.4

25-50% inhibition at 1 mM

745498

-

6.2.1.5

45-55% inhibition at 1 mM

745498

-

Enzyme Kinetic Parameters

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.8.4

0.074

-

versus isovaleryl-CoA, pH 8.0, 37°C

724826

1.8.1.4

1.43

-

-

691036

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486300

8440734

Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes

1993

Chung, C.D.; Bieber, L.L.

J. Biol. Chem.

268

4519-4524

650831

10362229

Characterization of a renal medium chain acyl-CoA synthetase responsible for glycine conjugation in mouse kidney mitochondria

1999

Kasuya, F.; Igarashi, K.; Fukui, M.

Chem. Biol. Interact.

118

233-246

691036

17706936

Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation

2007

Luis, P.B.; Ruiter, J.P.; Aires, C.C.; Soveral, G.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.

Biochim. Biophys. Acta

1767

1126-1133

724826

21430231

Role of isovaleryl-CoA dehydrogenase and short branched-chain acyl-CoA dehydrogenase in the metabolism of valproic acid: implications for the branched-chain amino acid oxidation pathway

2011

Luis, P.B.; Ruiter, J.P.; Ijlst, L.; Tavares de Almeida, I.; Duran, M.; Mohsen, A.W.; Vockley, J.; Wanders, R.J.; Silva, M.F.

Drug Metab. Dispos.

39

1155-1160

745498

24154984

Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate CoA ligases

2014

Luis, P.B.; Ruiter, J.; Ijlst, L.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.

J. Inherit. Metab. Dis.

37

353-357

Links to other databases for valproyl-CoA

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Show Links (1 entry)