Ligand S-methyl-L-cysteine

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Basic Ligand Information

Molecular Structure
Picture of S-methyl-L-cysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2S
S-methyl-L-cysteine
IDIDJDIHTAOVLG-VKHMYHEASA-N
Synonyms:
(S)-methyl-L-cysteine, (S)-methylcysteine, L-methylcysteine, L-S-methylcysteine, S-methyl-L-Cys, S-methylcysteine, S-methyl L-cysteine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-methyl-L-cysteine = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (60 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-methyl-L-cysteine + 2-oxoglutarate + O2 = S-methyl-L-cysteine (S)-sulfoxide + succinate + CO2
show the reaction diagram
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5-L-glutamylaniline + S-methyl-L-cysteine = aniline + 5-L-glutamyl-S-methyl-L-cysteine
show the reaction diagram
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2-oxosuccinamic acid + L-methylcysteine = L-asparagine + ?
show the reaction diagram
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glyoxylate + S-methyl-L-cysteine = glycine + 3-methylsulfanyl-2-oxopropanoate
show the reaction diagram
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S-methyl-L-cysteine + 2-oxoglutarate = 3-(methylthio)-2-oxopropanoic acid + L-glutamate
show the reaction diagram
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S-methyl-L-cysteine + glyoxylate = 3-methylsulfanyl-2-oxopropanoate + glycine
show the reaction diagram
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2-Oxobutanoate + S-methyl-L-Cys = ?
show the reaction diagram
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S-Methyl-L-cysteine + DL-homocysteine = ?
show the reaction diagram
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S-methyl-L-cysteine + H2O = sulfide + ?
show the reaction diagram
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S-methyl L-cysteine + H2O = ?
show the reaction diagram
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S-Methyl-L-Cys = S-Methyl-D-Cys
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + L-cysteine = S-adenosyl-L-homocysteine + S-methyl-L-cysteine
show the reaction diagram
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S-methyl-N-acetyl-L-cysteine + H2O = acetate + S-methyl-L-cysteine
show the reaction diagram
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5-L-glutamyl-S-methyl-L-cysteine = 5-oxoproline + S-methyl-L-cysteine
show the reaction diagram
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3-chloro-L-alanine + methylmercaptan = S-methyl-L-cysteine + Cl-
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
34% inhibition at 1 mM
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slight inhibition
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asparagine/pyruvate reaction
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substrate inhibition, when concentration exceeds 10 mM
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (281 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (26 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
5.95
-
pH and temperature not specified in the publication, addition of Brij 35 to the assay buffer

KM Value (54 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.85
-
pH 7.0, 30°C
13.13
-
pH 8.0, 37°C
1.26
-
pH and temperature not specified in the publication, addition of Brij 35 to the assay buffer

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.75
-
-

References & Links

Links to other databases for S-methyl-L-cysteine

ChEBI
PubChem
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PubChem