Ligand seleno-L-methionine

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Basic Ligand Information

Molecular Structure
Picture of seleno-L-methionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO2Se
seleno-L-methionine
RJFAYQIBOAGBLC-BYPYZUCNSA-N
Synonyms:
L-seleno-methionine, L-selenomethionine, L-selenomethionine[side 2], seleno-methionine, selenomethionine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + selenomethionine = S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
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selenomethionine + phenylpyruvate = 2-oxo-gamma-methylselenobutyrate + L-phenylalanine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + selenomethionine = S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
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ATP + L-selenomethionine + H2O = phosphate + diphosphate + Se-adenosyl-L-selenomethionine
show the reaction diagram
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selenomethionine + phenylpyruvate = 2-oxo-gamma-methylselenobutyrate + L-phenylalanine
show the reaction diagram
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seleno-L-methionine = methylselenol + 2-oxobutyrate + NH3
show the reaction diagram
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L-selenomethionine = HSe(CH3) + NH3 + 2-oxobutanoate
show the reaction diagram
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ATP + selenomethionine + tRNAMet = AMP + diphosphate + selenomethionyl-tRNAMet
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxo-4-methylselenobutyrate + NH3 + NADH = L-selenomethionine + H2O + NAD+
show the reaction diagram
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S-adenosyl-L-methionine + L-selenohomocysteine = selenomethionine + S-adenosyl-L-homocysteine
show the reaction diagram
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S-adenosylmethionine + L-selenohomocysteine = L-selenomethionine + S-adenosylhomocysteine
show the reaction diagram
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O-acetyl-L-homoserine + methylselenide = seleno-L-methionine + acetic acid
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N-acetylseleno-L-methionine + H2O = acetate + L-selenomethionine
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ATP + H2O + L-selenomethionine-[methionine-binding protein][side 1] = ADP + phosphate + L-selenomethionine[side 2] + [methionine-binding protein][side 1]
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.015 mM, 40% residual activity
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methionyl-tRNA formation
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Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.51
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References & Links

Links to other databases for seleno-L-methionine

ChEBI
PubChem
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PubChem