Ligand Lipoamide

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Basic Ligand Information

Molecular Structure
Picture of Lipoamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H15NOS2
Lipoamide
FCCDDURTIIUXBY-UHFFFAOYSA-N
Synonyms:
(R,S)-lipoamide, alpha-lipoamide, DL-alpha-lipoamide, DL-lipoamide, lipoamide disulfide, R,S-lipoamide
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for Lipoamide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2
show the reaction diagram
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2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2
show the reaction diagram
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pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2
show the reaction diagram
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2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lipoamide + H2O2 = ? + H2O
show the reaction diagram
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pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2
show the reaction diagram
-
2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2
show the reaction diagram
-
glycine + lipoamide = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADH + lipoamide = NAD+ + lipoamide
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the multienzyme complex catalyzes a thiamine diphosphate- and Mg2+-dependent oxidative decarboxylation of branched-chain keto acids with the formation of branched-chain acyl-CoA and reduction of NAD+ to NADH: R1R2CHCOCOOH + NAD+ + CoASH = R1R2CHCO-S-CoA + NADH + CO2, component E1 (EC 1.2.4.4, branched-chain keto acid dehydrogenase), component E2 (no EC number, branched-chain acyltransferase), component E3 (EC 1.8.1.4, dihydrolipoamide dehydrogenase), partial reactions catalyzed by the multienzyme complex: 1. R1R2CHCOCOOH + E1-(thiamine diphosphate) = E1-(thiamine diphosphate)-COHCHR1R2 + CO2, 2. E1-(thiamine diphosphate)-COHCHR1R2 + lipoyl-E2 = R1R2CHCO-SCoA + dihydrolipoyl-E2, 4. dihydrolipoyl-E2 + NAD+ = lipoyl-E2 + NADH
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binds three-fold more weakly than D,L-lipoic acid, competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (26 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
90.9
-
pH 7.4, 37°C

KM Value (37 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.04446
-
pH 7.4, 37°C
0.043
-
the apparent Km-value of rTvL for binding the free lipoamide

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Lipoamide

ChEBI
PubChem
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PubChem