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Ligand cortisol

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

androgen and estrogen metabolism

KEGG

Aldosterone-regulated sodium reabsorption, Bile secretion, Cortisol synthesis and secretion, Cushing syndrome, Glucocorticoid and mineralocorticoid receptor agonists/antagonists, Neuroactive ligand-receptor interaction, Pathways in cancer, Prostate cancer, Steroid hormone biosynthesis more

MetaCyc

glucocorticoid biosynthesis

Show all BRENDA pathways known for cortisol

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

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Show Natural Substrate (12 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.146

cortisol + NAD+ = cortisone + NADH

667962

-

1.1.1.146

cortisol + NAD+ = cortisone + NADH + H+

761000, 761757, 761758, 762011, 760956, 761665

-

1.1.1.146

cortisol + NADP+ = cortisone + NADPH

699847, 699842, 667152

-

1.1.1.146

cortisol + NADP+ = cortisone + NADPH + H+

740151, 740375, 741444, 740803, 740917, 740146, 760443, 760802, 740149, 761543, 740132, 741066

-

1.1.1.146

4 entries

1.1.1.149

cortisol + NADH + H+ = 20beta-hydroxycortisol + NAD+

763262

-

1.1.1.184

cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+

762424

-

1.1.1.B40

cortisol + beta-NAD+ = cortisone + beta-NADH

743434

-

1.1.1.B40

cortisol + NAD+ = cortisone + NADH

699842, 656350, 699847, 654889, 668426, 668379, 655162, 667152, 669907, 670896, 667151, 667962, 667148, 668425, 669706, 668297, 667956, 668505

-

1.1.1.B40

2 entries

1.14.15.4

cortisol + reduced adrenal ferredoxin + O2 = 11-deoxycortisol + adrenal ferredoxin + ?

690171

-

1.3.1.3

cortisol + NADPH = ?

390597

-

2.3.1.27

acetyl-CoA + cortisol = CoA + cortisol 21-acetate

486711

-

2.8.2.18

3'-phosphoadenylylsulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate

645771, 645772, 645766, 645722, 645768, 645769, 645770

-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

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Show Natural Product (7 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.146

cortisone + NAD(P)H = cortisol + NAD(P)+

0

-

1.1.1.146

cortisone + NADH + H+ = cortisol + NAD+

0

-

1.1.1.146

cortisone + NADPH + H+ = cortisol + NADP+

0

-

1.1.1.146

3 entries

1.1.1.B40

cortisone + NADPH + H+ = cortisol + NADP+

0

-

1.14.15.4

11-deoxy-cortisol + reduced ferredoxin + O2 = cortisol + ferredoxin + H2O

0

-

1.14.15.4

11-deoxycortisol + adrenal ferredoxin + H2O = cortisol + reduced adrenal ferredoxin + O2

0

-

1.14.15.4

11-deoxycortisol + reduced adrenal ferredoxin + O2 = cortisol + oxidized adrenal ferredoxin + H2O

0

-

1.14.15.4

3 entries

Substrate in Enzyme-catalyzed Reactions (36 results)

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Show Substrate (36 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.145

11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH = 3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+

389394

-

1.1.1.146

cortisol + NAD+ = cortisone + NADH

688766, 667962

-

1.1.1.146

cortisol + NAD+ = cortisone + NADH + H+

761000, 761757, 761758, 724519, 762011, 760956, 761665

-

1.1.1.146

cortisol + NADP+ = cortisone + NADPH

693886, 700121, 700180, 688766, 656356, 667152, 695146, 700181, 701241, 695409, 699847, 695090, 696570, 699713, 700179, 692338, 699842, 669419, 697737, 691275, 698026

-

1.1.1.146

cortisol + NADP+ = cortisone + NADPH + H+

740151, 740375, 741444, 740803, 740917, 740146, 760443, 760802, 740149, 761543, 740132, 741066

-

1.1.1.149

17alpha-hydroxycorticosterone + NADPH = ? + NADP+

285988

-

1.1.1.149

cortisol + NADH + H+ = 20beta-hydroxycortisol + NAD+

763262

-

1.1.1.149

cortisol + NADH = 20alpha-dihydrocortisol + NAD+

285979, 285994

-

1.1.1.146

4 entries

1.1.1.149

3 entries

1.1.1.184

cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+

762424

-

1.1.1.B40

cortisol + beta-NAD+ = cortisone + beta-NADH

743434

-

1.1.1.B40

cortisol + NAD+ = cortisone + NADH

688766, 693544, 699842, 667152, 656350, 693882, 699847, 695090, 654889, 668426, 725817, 668379, 655162, 669706, 669907, 670896, 667673, 667151, 668425, 667962, 667148, 668297, 667956, 668505

-

1.1.1.B40

cortisol + NAD+ = cortisone + NADH + H+

711737, 712257, 711471, 711694, 713232

-

1.1.1.B40

3 entries

1.14.13.54

Cortisol + NADPH + O2 = ?

7390

-

1.14.15.30

11beta-hydrocortisone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxy-11beta-hydrocortisone + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

717737, 717735

-

1.14.15.4

cortisol + reduced adrenal ferredoxin + O2 = 11-deoxycortisol + adrenal ferredoxin + ?

690171

-

1.14.15.4

cortisol + reduced adrenal ferredoxin + O2 = cortisone + oxidized adrenal ferredoxin + ?

285398

-

1.3.1.3

11beta,17alpha,21-trihydroxy-pregn-4-en-3,20-dione + NADPH = 11beta,17alpha,21-trihydroxypregnan-3,20-dione + NADP+

390646

-

1.3.1.3

cortisol + NADPH + H+ = 11beta,17,21-trihydroxy-5beta-pregnane-3,20-dione + NADP+

762900

-

1.3.1.3

cortisol + NADPH + H+ = ?

726492

-

1.3.1.3

cortisol + NADPH = 11beta,17,21-trihydroxy-5beta-pregnane-3,20-dione + NADP+

676735, 676376

-

1.3.1.3

cortisol + NADPH = ?

390591, 390594, 390597

-

1.3.99.4

11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + 2,6-dichlorphenolindophenol = 1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced 2,6-dichlorphenolindophenol

762654

-

1.3.99.4

11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor = 1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor

762654, 763735, 762659

-

1.3.99.4

11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + phenazine methosulfate = 1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced phenazine methosulfate

762654

-

1.3.99.4

11beta-cortisol + 2,6-dichlorophenol-indophenol = (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol

684994

-

1.3.99.4

cortisol + acceptor = prednisolone + reduced acceptor

657152

-

1.3.99.4

hydrocorticosterone + acceptor = 1,4-pregnene-11beta,17alpha,21-triol-3,20-dione + reduced acceptor

391375

-

1.14.15.4

2 entries

1.3.1.3

5 entries

1.3.99.4

6 entries

2.3.1.27

acetyl-CoA + cortisol = CoA + cortisol 21-acetate

486711

-

2.4.1.385

UDP-alpha-D-glucose + hydrocortisone = UDP + 11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl beta-D-glucopyranoside

691052

-

2.8.2.15

3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + ?

760621

-

2.8.2.15

3'-phosphoadenylylsulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol sulfate

645722

-

2.8.2.15

2 entries

2.8.2.18

3'-phosphoadenylylsulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate

645771, 645772, 645766, 645722, 645768, 645769, 645770

-

2.8.2.2

3'-phosphoadenylylsulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol sulfate

645774, 645776, 738909

-

2.8.2.2

3'-phosphoadenylylsulfate + hydrocortisone = adenosine 3',5'-bisphosphate + hydrocortisone sulfate

645776

-

2.8.2.2

2 entries

2.8.2.34

3'-phosphoadenylyl 5'-phosphosulfate + cortisol = adenosine 3',5'-bisphosphate + ?

659656

-

2.8.2.9

3'-phosphoadenylylsulfate + hydrocortisone = adenosine 3',5'-bisphosphate + ?

644826

-

Product in Enzyme-catalyzed Reactions (13 results)

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Show Product (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.146

cortisone + NAD(P)H = cortisol + NAD(P)+

0

-

1.1.1.146

cortisone + NADH + H+ = cortisol + NAD+

0

-

1.1.1.146

cortisone + NADPH + H+ = cortisol + NADP+

0

-

1.1.1.B40

cortisone + beta-NADPH = cortisol + beta-NADP+

0

-

1.1.1.B40

cortisone + NADPH + H+ = cortisol + NADP+

0

-

1.1.1.146

3 entries

1.1.1.B40

2 entries

1.14.14.16

11,17-dihydroxyprogesterone + NADH + O2 = cortisol + NAD+ + H2O

285439

-

1.14.15.4

17alpha,21-dihydroxy-pregn-4-ene-3,20-dione + reduced adrenal ferredoxin + O2 = 11beta,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione + oxidized adrenal ferredoxin + H2O

285388

-

1.14.15.4

11-deoxy-cortisol + reduced ferredoxin + O2 = cortisol + ferredoxin + H2O

0

-

1.14.15.4

11-deoxycortisol + adrenal ferredoxin + H2O = cortisol + reduced adrenal ferredoxin + O2

0

-

1.14.15.4

11-deoxycortisol + NADPH + O2 = cortisol + NADP+ + H2O

0

-

1.14.15.4

11-deoxycortisol + oxidized adrenodoxin + H2O = cortisol + reduced adrenodoxin + O2

0

-

1.14.15.4

11-deoxycortisol + reduced adrenal ferredoxin + O2 = cortisol + oxidized adrenal ferredoxin + H2O

0, 285407, 285405, 285409

-

1.14.15.4

11-deoxycortisol + reduced adrenodoxin + O2 = cortisol + oxidized adrenodoxin + H2O

0

-

1.14.15.4

7 entries

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.20

induces

439542

-

6.3.2.2

treatment of hepatocytes induces the expression of only the heavy enzyme subunit

650330

-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

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Show Inhibitors (11 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.189

-

389472

-

1.1.1.189

equimolar to substrate inhibits 55% of enzyme activity

389473

-

1.1.1.189

2 entries

1.1.1.21

i.e. cortisol

695881

-

1.1.1.213

competitive

347982

-

1.1.1.50

-

389527

-

1.3.99.4

optimal concentration is 0.1 mg/ml, increase of concentration to 1 mg/ml reduces prednisolone yield

657152

-

1.3.99.4

-

391379

-

1.3.99.4

2 entries

1.6.3.3

3 mM, 5% inhibition

722518

-

2.8.2.15

-

645722

-

2.8.2.18

inhibition above 0.08 mM

645772

-

3.1.4.17

-

135218

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (13 results)

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Show Turnover Number (13 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.146

0.04

-

37°C, pH 7.4, recombinant 11beta-HSD1 expressed in Escherichia coli

656133

1.1.1.146

0.042

-

pH 7.5, 22°C, recombinant wild-type isozyme 11beta-HSD1

669419

1.1.1.146

0.078

-

pH 7.5, 22°C, recombinant wild-type isozyme 11beta-HSD1 oxidized with K3Fe(CN)6

669419

1.1.1.146

0.19

-

37°C, pH 7.4, recombinant 11beta-HSD1 expressed in Escherichia coli

656133

1.1.1.146

4 entries

1.1.1.149

11.1

-

pH 5.0, temperature not specified in the publication

763262

1.3.1.3

0.00817

-

-

390591

1.3.1.3

0.045

-

pH 6.0, 37°C

726492

1.3.1.3

0.08

-

isoform AKR1D4L, pH 7, 37°C

762900

1.3.1.3

0.13

-

isoform AKR1D4S, pH 7, 37°C

762900

1.3.99.4

50.2

-

pH 8.0, 30°C

762654

1.3.99.4

60.3

-

pH 8.0, 25°C

762654

1.3.99.4

2842.34

-

recombinant enzyme, pH 8.0, 40°C

762659

1.3.1.3

4 entries

1.3.99.4

3 entries

2.8.2.2

0.183

-

pH 7.5, 37°C

645774

K_M Value (45 results)

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Show KM Value (45 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.145

0.0038

-

-

389394

1.1.1.146

0.000237

-

enzyme from caput epididymidis, cosubstrate NADP+, 37°C, pH not specified in the publication

695090

1.1.1.146

0.000254

-

enzyme from testis, cosubstrate NADP+, 37°C, pH not specified in the publication

695090

1.1.1.146

0.00034

-

37°C, pH 7.4, oxidation of cortisol by lysates of HEK-293 cells transfected with 11beta-HSD1

656227

1.1.1.146

0.000433

-

enzyme from bulbourethral gland, cosubstrate NADP+, 37°C, pH not specified in the publication

695090

1.1.1.146

0.0008

-

37°C, pH 7.4, oxidation of cortisol in intact HEK-293 cells transfected with 11beta-HSD1

656227

1.1.1.146

0.0017

-

37°C, pH 7.4, recombinant 11beta-HSD1

657253

1.1.1.146

0.002

-

kidney enzyme, pH 7.4, 37°C

654889

1.1.1.146

0.003

-

37°C, pH 7.4, recombinant 11beta-HSD1 expressed in Escherichia coli

656133

1.1.1.146

0.0065

-

pH 7.4, 28°C

695146

1.1.1.146

0.0096

-

pH 7.5, 22°C, recombinant wild-type isozyme 11beta-HSD1

669419

1.1.1.146

0.041

-

-

655216

1.1.1.146

0.041

-

37°C, pH 7.4, Hill coefficient of 1.0, no cooperative kinetic

654637

1.1.1.146

0.042

-

pH 7.5, 22°C, recombinant wild-type isozyme 11beta-HSD1 oxidized with K3Fe(CN)6

669419

1.1.1.146

0.1

-

37°C, pH 7.4, V149R mutant 11beta-HSD1, V149E mutant 11beta-HSD1, and N-terminal 15 amino acid truncated V149R and V149E mutant 11beta-HSD1

654698

1.1.1.149

0.02407

-

pH 5.0, temperature not specified in the publication

763262

1.1.1.149

0.032

-

NADH, pH 6.3

285979

1.1.1.B40

0.000154

-

enzyme from testis, cosubstrate NAD+, 37°C, pH not specified in the publication

695090

1.1.1.B40

0.0002

-

pH 7.4, 37°C

654889

1.1.1.B40

0.000208

-

enzyme from bulbourethral gland, cosubstrate NAD+, 37°C, pH not specified in the publication

695090

1.1.1.B40

0.000226

-

enzyme from caput epididymidis, cosubstrate NAD+, 37°C, pH not specified in the publication

695090

1.1.1.B40

0.00038

-

type 2 enzyme, 34°C, pH 7.4

693882

1.1.1.B40

0.00136

-

type 1 enzyme, 34°C, pH 7.4

693882

1.3.1.3

0.0071

-

isoform AKR1D4L, pH 7, 37°C

762900

1.3.1.3

0.011

-

-

390591

1.3.1.3

0.0114

-

isoform AKR1D4S, pH 7, 37°C

762900

1.3.1.3

0.0131

-

pH 6.0, 37°C

726492

1.3.1.3

0.291

-

-

676376

1.3.1.3

2.079

-

-

676735

1.3.99.4

0.0385

-

i.e. 4-pregnene-11beta,17alpha,21-triol-3,20-dione

391375

1.3.99.4

0.0401

-

pH 8.0, 25°C

762654

1.3.99.4

0.0463

-

pH 8.0, 30°C

762654

1.3.99.4

0.064

-

apparent value, in 50 mM Tris (pH 7.4), at 30°C

684994

1.3.99.4

0.557

-

apparent value, in 50 mM Tris (pH 7.4), at 30°C

684994

1.3.99.4

0.9158

-

recombinant enzyme, pH 8.0, 40°C

762659

1.1.1.146

14 entries

1.1.1.149

2 entries

1.1.1.B40

6 entries

1.3.1.3

6 entries

1.3.99.4

6 entries

2.8.2.15

0.00682

-

pH 6.8, 37.5°C

645722

2.8.2.18

0.00648

-

pH 6.8

645769

2.8.2.18

0.00682

-

pH 6.8, 37.5°C

645722

2.8.2.18

0.007

-

pH 6.8, sulfotransferase I and III

645768, 645771

2.8.2.18

0.007

0.02

-

645771

2.8.2.18

0.009

0.016

pH 6.8

645772

2.8.2.18

0.06

0.087

pH 6.8, 37.5°C

645766

2.8.2.2

0.29

-

pH 7.5, 37°C

645774

2.8.2.2

0.44

-

pH 7.5, 37°C

645774

2.8.2.18

6 entries

2.8.2.2

2 entries

2.8.2.9

0.012

-

pH 7, 25°C

644826

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.213

0.19

-

androsterone oxidation

347982

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.1.1.21

0.017

-

in 0.1 M potassium phosphate, pH 7.4, at 25°C

695881

References & Links

Literature References (126)

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Show Reference (126 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

7390

3486863

Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization

1986

Itagaki, E.

J. Biochem.

99

815-824

135218

6329099

Properties of a cyclic nucleotide phosphodiesterase of amphibian oocytes that is activated by calmodulin and calcium, by tryptic proteolysis, and by phospholipids

1984

Orellana, O.; Jedlicki, E.; Allende, C.C.; Allende, J.E.

Arch. Biochem. Biophys.

231

345-354

285388

4967077

Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata

1968

Zuidweg, M.H.J.

Biochim. Biophys. Acta

152

144-158

285398

2337351

Lipid regulation of bovine cytochrome P45011beta activity

1990

Seybert, D.

Arch. Biochem. Biophys.

279

188-194

285405

8431474

Photoaffinity labeling of cytochrome P-45011beta with methyltrienolone as a probe for the substrate binding region

1993

Ohnishi, T.; Miura, S.; Ichikawa, Y.

Biochim. Biophys. Acta

1161

257-264

285407

7663533

Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors

1995

Denner, K.; Vogel, R.; Schmalix, W.; Doehmer, J.; Bernhardt, R.

Pharmacogenetics

5

89-96

285409

8268203

Purification and properties of cytochrome P-450 (P-450lun) catalyzing steroid 11beta-hydroxylation in Curvularia lunata

1993

Suzuki, K.; Sanga, K.i.; Chikaoka, Y.; Itagaki, E.

Biochim. Biophys. Acta

1203

215-223

285439

13416221

Hydroxylation of steroids at carbon 21

1957

Ryan, K.J.; Engel, L.L.

J. Biol. Chem.

225

103-114

285979

2722736

Purification and characterization of a novel form of 20alpha-hydroxysteroid dehydrogenase from Clostridium scindens

1989

Krafft, A.E.; Hylemon, P.B.

J. Bacteriol.

171

2925-2932

285988

4400473

20alpha-Hydroxysteroid dehydrogenase of porcine testes

1972

Sato, F.; Takagi, Y.; Shikita, M.

J. Biol. Chem.

247

815-823

285994

3475510

Cofactor requirements of steroid-17-20-desmolase and 20alpha-hydroxysteroid dehydrogenase ativities in cell extracts of Clostridium scindens

1987

Krafft, A.E.; Winter, J.; Bokkenheuser, V.D.; Hylemon, P.B.

J. Steroid Biochem.

28

49-54

347982

6435601

Purification and properties of a 3alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs

1984

Penning, T.M.; Mukharji, I.; Barrows, S.; Talalay, P.

Biochem. J.

222

601-611

389394

7841933

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Gillespie, P.; Pietranico-Cole, S.; Myers, M.; Bilotta, J.A.; Conde-Knape, K.; Fotouhi, N.; Goodnow, R.A.; Guertin, K.R.; Hamilton, M.M.; Haynes, N.E.; Liu, B.; Qi, L.; Ren, Y.; Scott, N.R.; So, S.S.; Spence, C.; Taub, R.; Thakkar, K.; Tilley, J.W.; Zwingelstein, C.

Bioorg. Med. Chem. Lett.

24

2707-2711

740149

24360604

Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)

2014

Ye, X.Y.; Yoon, D.; Chen, S.Y.; Nayeem, A.; Golla, R.; Seethala, R.; Wang, M.; Harper, T.; Sleczka, B.G.; Apedo, A.; Li, Y.X.; He, B.; Kirby, M.; Gordon, D.A.; Robl, J.A.

Bioorg. Med. Chem. Lett.

24

654-660

740151

26187704

Discovery of 11beta-hydroxysteroid dehydrogenase type 1 inhibitor

2015

Hong, S.P.; Nam, K.Y.; Shin, Y.J.; Kim, K.W.; Ahn, S.K.

Bioorg. Med. Chem. Lett.

25

3501-3506

740375

26438395

The activity of 11beta-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas

2016

Morelli, V.; Polledri, E.; Mercadante, R.; Zhukouskaya, V.; Palmieri, S.; Beck-Peccoz, P.; Spada, A.; Fustinoni, S.; Chiodini, I.

Endocrine

53

809-815

740803

25303491

11beta-hydroxysteroid dehydrogenase types 1 and 2 activity in subcutaneous adipose tissue in humans: implications in obesity and diabetes

2015

Dube, S.; Norby, B.J.; Pattan, V.; Carter, R.E.; Basu, A.; Basu, R.

J. Clin. Endocrinol. Metab.

100

E70-E76

740917

25066675

Endocrine disruptors and other inhibitors of 11beta-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition

2016

Vitku, J.; Starka, L.; Bicikova, M.; Hill, M.; Heracek, J.; Sosvorova, L.; Hampl, R.

J. Steroid Biochem. Mol. Biol.

155

207-216

741066

25227721

11beta-Hydroxysteroid dehydrogenase enzymes modulate effects of glucocorticoids in rheumatoid arthritis synovial cells

2015

Schmidt, M.; Straub, R.H.

Neuroimmunomodulation

22

40-45

741444

27025972

Expression of 11beta-hydroxysteroid-dehydrogenase type 2 in human thymus

2016

Almanzar, G.; Mayerl, C.; Seitz, J.C.; Hoefner, K.; Brunner, A.; Wild, V.; Jahn, D.; Geier, A.; Fassnacht, M.; Prelog, M.

Steroids

110

35-40

743434

26654513

Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS

2016

Heussner, K.; Ruebner, M.; Huebner, H.; Rascher, W.; Menendez-Castro, C.; Hartner, A.; Fahlbusch, F.B.; Rauh, M.

Placenta

37

79-84

760443

32880710

Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity

2021

Huebner, H.; Heussner, K.; Ruebner, M.; Schmid, M.; Nadal, J.; Woelfle, J.; Hartner, A.; Menendez-Castro, C.; Rauh, M.; Beckmann, M.W.; Kehl, S.; Fahlbusch, F.B.

Arch. Gynecol. Obstet.

303

401-408

760621

28782626

DELTA4-3-ketosteroids as a new class of substrates for the cytosolic sulfotransferases

2017

Hashiguchi, T.; Kurogi, K.; Shimohira, T.; Teramoto, T.; Liu, M.C.; Suiko, M.; Sakakibara, Y.

Biochim. Biophys. Acta

1861

2883-2890

760802

28797028

Characterisation of the cancer-associated glucocorticoid system key role of 11beta-hydroxysteroid dehydrogenase type 2

2017

Cirillo, N.; Morgan, D.J.; Pedicillo, M.C.; Celentano, A.; Lo Muzio, L.; McCullough, M.J.; Prime, S.S.

Br. J. Cancer

117

984-993

760956

28932959

The role and regulation of the 11 beta-hydroxysteroid dehydrogenase enzyme system in patients with inflammatory bowel disease

2017

Hussey, M.; Holleran, G.; Smith, S.; Sherlock, M.; McNamara, D.

Digest. Dis. Sci.

62

3385-3390

761000

28366868

Recent advances in the study of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) inhibitors

2017

Zhou, C.; Ye, F.; Wu, H.; Ye, H.; Chen, Q.

Environ. Toxicol. Pharmacol.

52

47-53

761543

31674280

Structural assessment and identification of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors

2020

Ganjoo, A.; Tripathi, A.; Chetti, P.

J. Biomol. Struct. Dyn.

38

4928-4937

761665

31273032

11beta-Hydroxysteroid dehydrogenases control access of 7beta,27-dihydroxycholesterol to retinoid-related orphan receptor gamma

2019

Beck, K.R.; Inderbinen, S.G.; Kanagaratnam, S.; Kratschmar, D.V.; Jetten, A.M.; Yamaguchi, H.; Odermatt, A.

J. Lipid Res.

60

1535-1546

761757

30825506

The 11beta-hydroxysteroid dehydrogenase isoforms pivotal catalytic activities yield potent C11-oxy C19 steroids with 11betaHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

2019

Gent, R.; du Toit, T.; Bloem, L.M.; Swart, A.C.

J. Steroid Biochem. Mol. Biol.

189

116-126

761758

30902677

Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2

2019

Beck, K.R.; Kanagaratnam, S.; Kratschmar, D.V.; Birk, J.; Yamaguchi, H.; Sailer, A.W.; Seuwen, K.; Odermatt, A.

J. Steroid Biochem. Mol. Biol.

190

19-28

762011

30884491

The role of 11beta-hydroxy steroid dehydrogenase type 2 in glucocorticoid programming of affective and cognitive behaviours

2019

Shearer, F.J.G.; Wyrwoll, C.S.; Holmes, M.C.

Neuroendocrinology

109

257-265

762424

28878267

Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

2017

Morgan, R.A.; Beck, K.R.; Nixon, M.; Homer, N.Z.M.; Crawford, A.A.; Melchers, D.; Houtman, R.; Meijer, O.C.; Stomby, A.; Anderson, A.J.; Upreti, R.; Stimson, R.H.; Olsson, T.; Michoel, T.; Cohain, A.; Ruusalepp, A.; Schadt, E.E.; Bjoerkegren, J.L.M.; Andrew, R.; Kenyon, C.J.; Hadoke, P.W.F.; Odermatt, A.; Keen, J.

Sci. Rep.

7

10633

762654

28634849

Characterization of new recombinant 3-ketosteroid-DELTA1-dehydrogenases for the biotransformation of steroids

2017

Wang, X.; Feng, J.; Zhang, D.; Wu, Q.; Zhu, D.; Ma, Y.

Appl. Microbiol. Biotechnol.

101

6049-6060

762659

31289904

Purification, characterization, and application of a high activity 3-ketosteroid-DELTA1-dehydrogenase from Mycobacterium neoaurum DSM 1381

2019

Zhang, R.; Xu, X.; Cao, H.; Yuan, C.; Yuminaga, Y.; Zhao, S.; Shi, J.; Zhang, B.

Appl. Microbiol. Biotechnol.

103

6605-6616

762900

30928400

Human and murine steroid 5beta-reductases (AKR1D1 and AKR1D4) insights into the role of the catalytic glutamic acid

2019

Chen, M.; Wangtrakuldee, P.; Zang, T.; Duan, L.; Gathercole, L.L.; Tomlinson, J.W.; Penning, T.M.

Chem. Biol. Interact.

305

163-170

763262

31209107

Structural and biochemical characterization of 20-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

2019

Doden, H.; Pollet, R.; Mythen, S.; Wawrzak, Z.; Devendran, S.; Cann, I.; Koropatkin, N.; Ridlon, J.

J. Biol. Chem.

294

12040-12053

763735

30979909

Development of a synthetic 3-ketosteroid DELTA1-dehydrogenase for the generation of a novel catabolic pathway enabling cholesterol degradation in human cells

2019

D'Arcy, B.M.; Swingle, M.R.; Schambeau, L.; Pannell, L.; Prakash, A.; Honkanen, R.E.

Sci. Rep.

9

5969

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