Ligand Isonicotinic acid

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Basic Ligand Information

Molecular Structure
Picture of Isonicotinic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H5NO2
Isonicotinic acid
TWBYWOBDOCUKOW-UHFFFAOYSA-N
Synonyms:
4-Carboxypyridine, 4-Pyridinecarboxylate, 4-Pyridinecarboxylic acid, 4-pyridine carboxylic acid, gamma-picolinic acid, isonicotinate, pyridine-4-carboxylate, pyridine-4-carboxylic acid, Pyridine 4-carboxylate, pyridine 4-carboxylic acid, pyridine 4-formiate
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-cyanopyridine + 2 H2O = pyridine 4-carboxylic acid + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Pyridine 4-carboxylate + reduced carbamoyl methyl viologen = Pyridine 4-carboxaldehyde + carbamoyl methyl viologen
show the reaction diagram
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S-adenosyl-L-methionine + isonicotinate = S-adenosyl-L-homocysteine + isonicotinic acid methyl ester
show the reaction diagram
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thiamine + 4-pyridinecarboxylic acid = 4-methyl-5-(2-hydroxyethyl)-thiazole + 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-carboxypyridinium
show the reaction diagram
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ATP + isonicotinate + CoA = AMP + diphosphate + isonicotinyl-CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-pyridine carboxaldehyde + NAD+ + H2O = 4-pyridine carboxylic acid + NADH + 2 H+
show the reaction diagram
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pyridine 4-carboxyaldehyde + NAD+ + H2O = pyridine 4-formiate + NADH
show the reaction diagram
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pyridine 4-carboxyaldehyde + NAD+ + H2O = pyridine 4-carboxylate + NADH
show the reaction diagram
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4-pyridinecarboxaldehyde + NAD+ + H2O = 4-pyridinecarboxylate + NADH + H+
show the reaction diagram
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4-carboxypyridine N-oxide + reduced benzyl viologen + H2O = 4-carboxypyridine + oxidized benzyl viologen
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor with respect to 2-oxoglutarate, noncompetitive with respect to Fe2+
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hydroxylamine reductase 2, slight
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98% inhibition at 1 mM
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non-competitive inhibitor, Ki: 8.3 mM
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.4
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Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.9
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8.3
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References & Links

Links to other databases for Isonicotinic acid

ChEBI
PubChem
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PubChem