Ligand vigabatrin

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Basic Ligand Information

Molecular Structure
Picture of vigabatrin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H11NO2
vigabatrin
PJDFLNIOAUIZSL-UHFFFAOYSA-N
Synonyms:
4-Amino-5-hexenoic acid, 4-Amino-hex-5-enoic acid, 4-aminohex-5-enoic acid, gamma-vinyl 4-aminobutanoate, vinyl-GABA

Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
structural analogue to gamma-amino butyric acid, anti-epilepsy drug, 1 mM, approx. 80% inhibition in vitro, in vivo alanine aminotransferase activity is reduced 30-40% 1-2h after administration
-

Enzyme Kinetic Parameters

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.62
-
forward reaction with 4-aminobutanoate and pyruvate, pH 9.0, 30C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.35
-
IC50: 0.35 mM

References & Links

Links to other databases for vigabatrin

ChEBI
PubChem
ChEBI
PubChem