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Ligand dihydrostreptomycin 6-phosphate

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.88

ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3''alpha,6-bisphosphate

641919, 642071

-

3.1.3.39

dihydrostreptomycin 6-phosphate + H2O = dihydrostreptomycin + phosphate

134853, 134855

-

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.87

ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'',6-diphosphate

642067

-

2.7.1.88

ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3''alpha,6-bisphosphate

641919, 642071

-

3.1.3.39

1,3-diamino-1,3-dideoxy-scyllo-inositol + dihydrostreptomycin 6-phosphate = ?

134855

-

3.1.3.39

2-deoxystreptamine + dihydrostreptomycin 6-phosphate = ?

134855

-

3.1.3.39

dihydrostreptomycin 6-phosphate + H2O = dihydrostreptomycin + phosphate

134853, 81100, 134855

-

3.1.3.39

3 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.72

ATP + dihydrostreptomycin = ADP + dihydrostreptomycin 6-phosphate

641921, 641918, 641919, 641920

-

Enzyme Kinetic Parameters

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

81100

4331203

Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate

1971

Walker, M.S.; Walker, J.B.

J. Biol. Chem.

246

7034-7040

134853

48998

Streptomycin-6-P phosphohydrolase

1975

Walker, J.B.

Methods Enzymol.

43

465-470

134855

4121457

Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine

1973

Walker, J.B.; Skorvaga, M.

J. Biol. Chem.

248

2441-2446

641918

6075410

Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate

1967

Walker, J.B.; Walker, M.S.

Biochim. Biophys. Acta

148

335-341

641919

4121456

Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives

1973

Walker, J.B.; Skorvaga, M.

J. Biol. Chem.

248

2435-2440

641920

166285

ATP:streptomycin 6-phosphotransferase

1975

Walker, J.B.

Methods Enzymol.

43

628-632

641921

6313852

Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin-producing micro-organism

1983

Sugiyama, M.; Sakamoto, M.; Mochizuki, H.; Nimi, O.; Nomi, R.

J. Gen. Microbiol.

129

1683-1687

642067

49000

ATP:streptomycin 3'‘-phosphotransferase

1975

Walker, J.B.; Walker, M.S.

Methods Enzymol.

43

632-634

642071

49001

ATP-:dihydrostreptomycin-6-P 3alpha-phosphotransferase

1975

Walker, J.B.; Walker, M.S.

Methods Enzymol.

43

634-637

Links to other databases for dihydrostreptomycin 6-phosphate

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Show Links (1 entry)