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The relationship between the chemical structure of aflatoxins and their effect on bovine pancreas deoxyribonuclease
1970
Schabort, J.C.; Pitout, M.J.
Enzymologia
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Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
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Bioessays
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ATP-dependent transport of aflatoxin B1 and its glutathione conjugate by the product of the multidrug resistance protein (MRP) gene
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Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis
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Biochemistry
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Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein
2001
Wang, E.J.; Casciano, C.N.; Clement, R.P.; Johnson, W.W.
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ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry
2004
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A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein
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The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane
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Proc. Natl. Acad. Sci. USA
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In vitro inhibitory effect of aflatoxin B1 on acetylcholinesterase activity in mouse brain
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Toxicology
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Toxicity of aflatoxin B1 to Helicoverpa zea and bioactivation by cytochrome P450 monooxygenases
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Cloning and expression of Penicillium minioluteum dextranase in Saccharomyces cerevisiae and its exploitation as a reporter in the detection of mycotoxins
2006
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Interaction of tomato lectin with ABC transporter in cancer cells: Glycosylation confers functional conformation of P-gp
2009
Molnar, J.; Kars, M.D.; Guenduez, U.; Engi, H.; Schumacher, U.; Van Damme, E.J.; Peumans, W.J.; Makovitzky, J.; Gyemant, N.; Molnar, P.
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Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter
2008
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Biochem. Pharmacol.
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Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport
2008
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Biochemistry
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Conformational change induced by ATP binding in the multidrug ATP-binding cassette transporter BmrA
2008
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Biochemistry
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Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1
2009
Crowley, E.; OMara, M.L.; Reynolds, C.; Tieleman, D.P.; Storm, J.; Kerr, I.D.; Callaghan, R.
Biochemistry
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A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans
2008
Rai, V.; Gaur, M.; Kumar, A.; Shukla, S.; Komath, S.S.; Prasad, R.
Biochim. Biophys. Acta
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The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport
2009
Puri, N.; Gaur, M.; Sharma, M.; Shukla, S.; Ambudkar, S.V.; Prasad, R.
Biochim. Biophys. Acta
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The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues
2009
Szeri, F.; Ilias, A.; Pomozi, V.; Robinow, S.; Bakos, E.; Varadi, A.
Biochim. Biophys. Acta
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Methoxylation of 3,4-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells
2008
Fong, W.F.; Shen, X.L.; Globisch, C.; Wiese, M.; Chen, G.Y.; Zhu, G.Y.; Yu, Z.L.; Tse, A.K.; Hu, Y.J.
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Molecular models of human P-glycoprotein in two different catalytic states
2009
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Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B
2009
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Cancer Res.
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Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP
2009
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Cancer Res.
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Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids
2009
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Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
2008
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Drug Metab. Dispos.
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Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens
2009
Arias, A.; Villanueva, S.S.; Ruiz, M.L.; Luquita, M.G.; Veggi, L.M.; Pellegrino, J.M.; Vore, M.; Catania, V.A.; Mottino, A.D.
Drug Metab. Dispos.
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Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone
2009
Lagas, J.S.; van der Kruijssen, C.M.; van de Wetering, K.; Beijnen, J.H.; Schinkel, A.H.
Drug Metab. Dispos.
37
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Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice
2009
Cui, Y.J.; Cheng, X.; Weaver, Y.M.; Klaassen, C.D.
Drug Metab. Dispos.
37
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Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2)
2008
Yasunaga, M.; Takemura, M.; Fujita, K.; Yabuuchi, H.; Wada, M.
Eur. J. Pharm. Sci.
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Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
2008
Nabekura, T.; Yamaki, T.; Kitagawa, S.
Eur. J. Pharmacol.
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Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania
2008
Jimenez-Alonso, S.; Perez-Lomas, A.L.; Estevez-Braun, A.; Munoz Martinez, F.; Chavez Orellana, H.; Ravelo, A.G.; Gamarro, F.; Castanys, S.; Lopez, M.
J. Med. Chem.
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Rhodamine inhibitors of P-glycoprotein: an amide/thioamide switch for ATPase activity
2009
Gannon, M.K.; Holt, J.J.; Bennett, S.M.; Wetzel, B.R.; Loo, T.W.; Bartlett, M.C.; Clarke, D.M.; Sawada, G.A.; Higgins, J.W.; Tombline, G.; Raub, T.J.; Detty, M.R.
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Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux
2009
Karla, P.K.; Quinn, T.L.; Herndon, B.L.; Thomas, P.; Pal, D.; Mitra, A.
J. Ocul. Pharmacol. Ther.
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A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport
2008
Yang, Z.; Wu, D.; Bui, T.; Ho, R.J.
J. Pharmacol. Exp. Ther.
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Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility
2009
Messerli, S.M.; Kasinathan, R.S.; Morgan, W.; Spranger, S.; Greenberg, R.M.
Mol. Biochem. Parasitol.
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Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1)
2009
Conseil, G.; Rothnie, A.J.; Deeley, R.G.; Cole, S.P.
Mol. Pharmacol.
75
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Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol
2009
van de Wetering, K.; Burkon, A.; Feddema, W.; Bot, A.; de Jonge, H.; Somoza, V.; Borst, P.
Mol. Pharmacol.
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Substrates and modulators of the multidrug transporter Cdr1p of Candida albicans in antifungal extracts of medicinal plants
2010
Kolaczkowski, M.; Kolaczkowska, A.; Sroda, K.; Ramalhete, C.; Michalak, K.; Mulhovo, S.; Ferreira, M.J.
Mycoses
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Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells
2009
Kodan, A.; Shibata, H.; Matsumoto, T.; Terakado, K.; Sakiyama, K.; Matsuo, M.; Ueda, K.; Kato, H.
Protein Expr. Purif.
66
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Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
2008
Russel, F.G.; Koenderink, J.B.; Masereeuw, R.
Trends Pharmacol. Sci.
29
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Modulation of anticancer drug-induced P-glycoprotein expression by naringin
2009
Ali, M.M.; Agha, F.G.; El-Sammad, N.M.; Hassan, S.K.
Z. Naturforsch. C
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At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17
2011
Gilep, A.A.; Sushko, T.A.; Usanov, S.A.
Biochim. Biophys. Acta
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Detoxification of aflatoxin B1 by manganese peroxidase from the white-rot fungus Phanerochaete sordida YK-624
2011
Wang, J.; Ogata, M.; Hirai, H.; Kawagishi, H.
FEMS Microbiol. Lett.
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The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters
2015
Golin, J.; Ambudkar, S.V.
Biochem. J.
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Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance
2014
Swartz, D.J.; Mok, L.; Botta, S.K.; Singh, A.; Altenberg, G.A.; Urbatsch, I.L.
Biosci. Rep.
34
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The saci_2123 gene of the hyperthermoacidophile Sulfolobus acidocaldarius encodes an ATP-binding cassette multidrug transporter
2015
Yang, N.; Driessen, A.J.
Extremophiles
19
101-108
Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1)
2012
Ebert, S.P.; Wetzel, B.; Myette, R.L.; Conseil, G.; Cole, S.P.; Sawada, G.A.; Loo, T.W.; Bartlett, M.C.; Clarke, D.M.; Detty, M.R.
J. Med. Chem.
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ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1
2017
Arana, M.R.; Altenberg, G.
Curr. Med. Chem.
25
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