Ligand aflatoxin B1

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Basic Ligand Information

Molecular Structure
Picture of aflatoxin B1 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C17H12O6
aflatoxin B1
OQIQSTLJSLGHID-WNWIJWBNSA-N
Synonyms:
aflatoxin B[side 1], aflatoxin B[side 2]


Show all pahtways known for Show all BRENDA pathways known for aflatoxin B1

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-O-methylsterigmatocystin + [reduced NADPH-hemoprotein reductase] + O2 = aflatoxin B1 + 2 NADP+ + methanol + [oxidized NADPH-hemoprotein reductase] + H2O + CO2
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ATP + H2O + xenobiotic/in = ADP + phosphate + xenobiotic/out
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 Mn2+ + H2O2 + aflatoxin B1 = 2 Mn3+ + aflatoxin B1-8,9-dihydrodiol
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aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 = ?
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aflatoxin B1 + AH2 + O2 = aflatoxin B1epoxide + A + H2O
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-O-methylsterigmatocystin + [reduced NADPH-hemoprotein reductase] + O2 = aflatoxin B1 + 2 NADP+ + methanol + [oxidized NADPH-hemoprotein reductase] + H2O + CO2
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
effective activator below 0.08 mM
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.031 mM by increase of Km-value and decrease of vmax-value. Partial recativation by 2-aldoxime, i.e. 2-PAM, pyridin-2-aldoxime 1-methoiodide
inhibits dextranase activities of CYP3A4-expressing cultures, maximum inhibition of 22% at 2 microg/ml. Only negligibly inhibits strain INVSC1 expressing dextranase
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

References & Links

Links to other databases for aflatoxin B1

ChEBI
PubChem
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PubChem