Ligand 8-azahypoxanthine
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Basic Ligand Information
Molecular Structure
C4H3N5O
8-azahypoxanthine
OEEYCNOOAHGFHL-UHFFFAOYSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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8-azahypoxanthine + NAD+ + H2O = 8-azaxanthine + NADH
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8-azahypoxanthine + alpha-D-ribose 1-phosphate = 8-azainosine + phosphate
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8-azahypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate = 8-aza-IMP + diphosphate
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Product in Enzyme-catalyzed Reactions (1 result)
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8-azainosine + H2O = 8-azahypoxanthine + D-ribose
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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40% inhibition of xanthine dehydrogenase at 0.25 mM
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Enzyme Kinetic Parameters
KM Value (2 results)
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Ki Value (1 result)
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References & Links
Literature References (5)
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Purine nucleoside phosphorylases: properties, functions, and clinical aspects
2000
Bzowska, A.; Kulikowska, E.; Shugar, D.
Pharmacol. Ther.
88
349-425
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii
1995
Naguib, F.N.M.; Iltzsch, M.H.; el Kouni, M.M.; Panzica, R.P.; el Kouni, M.H.
Biochem. Pharmacol.
50
1685-1693
Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae
1987
Schimandle, C.M.; Mole, L.A.; Sherman, I.W.
Mol. Biochem. Parasitol.
23
39-45
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Molecular and kinetic characterization of xanthine dehydrogenase from the phototrophic bacterium Rodopseudomonas capsulata
1981
Aretz, W.; Kaspari, H.; Klemme, J.H.
Z. Naturforsch. C
36
933-941
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Purification, crystallization, and some properties of xanthine dehydrogenase from Pseudomonas synxantha A 3
1979
Sakai, T.; Jun, H.K.
Agric. Biol. Chem.
43
753-760
Links to other databases for 8-azahypoxanthine
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