Ligand dihydroorotate

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Basic Ligand Information

Molecular Structure
Picture of dihydroorotate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6N2O4
dihydroorotate
IGVPBCZDHMIOJH-UHFFFAOYSA-N
Synonyms:
D-dihydroorotate, dihydro-DL-orotate, dihydroorotic acid
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for dihydroorotate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroorotate + NAD+ = orotate + NADH + H+
show the reaction diagram
-
dihydroorotate + acceptor = orotate + reduced acceptor
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydroorotic acid + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM
-
slight inhibition
-
competitive inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
127
-
-

KM Value (40 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
18.6
-
pH 8.0, 25C, recombinant enzyme

References & Links

Links to other databases for dihydroorotate

ChEBI
PubChem
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PubChem