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Ligand dihydroorotate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for dihydroorotate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

PROVEN IN VIVO REACTION

ENZYME 3D STRUCTURE

1.3.1.14

390562, 390568, 390569, 390565, 390561

dihydroorotate + NAD+ = orotate + NADH + H+

-

1.3.5.2

391223, 391227, 391221

dihydroorotate + acceptor = orotate + reduced acceptor

-

Substrate in Enzyme-catalyzed Reactions (36 results)

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Show Substrate (36 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

1.3.1.14

390917, 390928

dihydroorotate + acceptor = orotate + reduced acceptor

-

1.3.1.14

654759, 390562, 390568, 390569, 390565, 390561

dihydroorotate + NAD+ = orotate + NADH + H+

-

1.3.5.2

673547

dihydroorotate + 2,3-dimethoxy-5-methyl-1,4-benzoquinone = orotate + reduced 2,3-dimethoxy-5-methyl-1,4-benzoquinone

-

1.3.5.2

655559

dihydroorotate + 2,5-dimethyl-p-benzoquinone = orotate + reduced 2,5-dimethyl-p-benzoquinone

-

1.3.5.2

655723

dihydroorotate + 2,5-dimethylbenzoquinone = orotate + reduced 2,5-dimethylbenzoquinone

-

1.3.5.2

673547

dihydroorotate + 2,6-dichloroindophenol = orotate + reduced 2,6-dichloroindophenol

-

1.3.5.2

655723, 675294, 656747

dihydroorotate + 2,6-dichlorophenolindophenol = orotate + reduced 2,6-dichlorophenolindophenol

-

1.3.5.2

390926, 672109, 390919, 391229, 391233, 391242, 391226, 390929, 391224, 391221, 391227, 391235, 675614, 391223, 675315, 390930, 390925, 391241

dihydroorotate + acceptor = orotate + reduced acceptor

-

1.3.5.2

698938

dihydroorotate + coenzyme Q = orotate + reduced coenzyme Q

-

1.3.5.2

696249

dihydroorotate + coenzyme Q1 = orotate + reduced coenzyme Q1

-

1.3.5.2

696249

dihydroorotate + coenzyme QD = orotate + reduced coenzyme QD

-

1.3.5.2

655559

dihydroorotate + CoQ0 = orotate + reduced CoQo

-

1.3.5.2

655559, 655723

dihydroorotate + decylplastoquinone = orotate + reduced decylplastoquinone

-

1.3.5.2

673547, 655559, 655723

dihydroorotate + decylubiquinone = orotate + reduced decylubiquinone

-

1.3.5.2

655559, 655723

dihydroorotate + menadione = orotate + reduced menadione

-

1.3.5.2

696249

dihydroorotate + O2 = orotate + H2O2

-

1.3.5.2

673547

dihydroorotate + potassium hexacyanoferrate(III) = orotate + reduced potassium hexacyanoferrate(III)

-

1.3.5.2

673547

dihydroorotate + ubiquinone 30 = orotate + reduced ubiquinone 30

-

1.3.5.2

673547

dihydroorotate + ubiquinone 50 = orotate + reduced ubiquinone 50

-

1.3.5.2

655723

dihydroorotate + ubiquinone-0 = orotate + reduced ubiquinone-0

-

1.3.5.2

655723

dihydroorotate + ubiquinone-10 = orotate + reduced ubiquinone-10

-

1.3.5.2

655559

dihydroorotate + ubiquinone-50 = orotate + reduced ubiquinone-50

-

1.3.98.1

671050

dihydroorotate + 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone = orotate + reduced 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone

-

1.3.98.1

671050

dihydroorotate + 2,6-dichloroindophenol = orotate + reduced 2,6-dichloroindophenol

-

1.3.98.1

655517

dihydroorotate + 2,6-dichlorophenolindophenol = orotate + ?

-

1.3.98.1

656148, 685158, 656747

dihydroorotate + 2,6-dichlorophenolindophenol = orotate + reduced 2,6-dichlorophenolindophenol

-

1.3.98.1

390927, 390916, 390915, 391222

dihydroorotate + acceptor = orotate + reduced acceptor

-

1.3.98.1

655517

dihydroorotate + ferricyanide = orotate + ferrocyanide

-

1.3.98.1

656148, 676289, 656747, 675478

dihydroorotate + fumarate = orotate + ?

-

1.3.98.1

676859, 676289, 676964

dihydroorotate + fumarate = orotate + reduced fumarate

-

1.3.98.1

684848

dihydroorotate + fumarate = orotate + succinate

-

1.3.98.1

656148, 656747, 655517

dihydroorotate + O2 = orotate + H2O2

-

1.3.98.1

684848

dihydroorotate + ubiquinone-1 = orotate + ubiquinol-1

-

1.3.1.14

2 entries

1.3.5.2

20 entries

1.3.98.1

11 entries

3.5.2.2

209290

dihydroorotic acid + H2O = ?

-

3.5.2.3

652558, 670191, 667595

dihydroorotate + H2O = N-carbamoyl-L-aspartate

-

3.5.2.3

246634

dihydro-DL-orotate + H2O = N-carbamoyl-L-aspartate

-

3.5.2.3

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

3.5.2.3

-

N-carbamoyl-DL-aspartate = dihydroorotate + H2O

-

3.5.2.3

-

N-carbamoyl-L-aspartate = dihydroorotate

-

3.5.2.3

2 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

COMMENTARY

EC NUMBER

LITERATURE

ENZYME 3D STRUCTURE

10 mM

2.4.2.10

489712

-

slight inhibition

3.5.2.2

758121

-

competitive inhibition

3.5.2.5

733422

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (10 results)

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Show Turnover Number (10 entries)

COMMENTARY

EC NUMBER

LITERATURE

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

-

1.3.5.2

391226

50.4

-

full-length DHODH

1.3.5.2

673547

2.1

-

mutant F188A

1.3.5.2

675315

12.3

-

mutant H185A

1.3.5.2

675315

1.4

-

mutant R265K

1.3.5.2

675315

16.1

-

N-terminally truncated DHODH

1.3.5.2

673547

2.2

-

pH 8.0, 30°C, DELTA1-75 mutant

1.3.5.2

655559

72.9

-

pH 8.0, 30°C, wild-type

1.3.5.2

655559

8.2

-

wild-type

1.3.5.2

675315

15.8

-

-

3.5.2.3

246634

127

-

K_M Value (40 results)

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Show KM Value (40 entries)

COMMENTARY

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

LITERATURE

-

1.3.5.2

0.009

-

391226

wild-type recombinant enzyme

1.3.5.2

0.017

-

655723

wild-type

1.3.5.2

0.013

-

675315

recombinant enzyme

1.3.5.2

0.015

-

390926

pH 8.0, 30°C, wild-type

1.3.5.2

0.04

-

655559

pH 8.0, 30°C, DELTA1-75 mutant

1.3.5.2

0.121

-

655559

N-terminally truncated DHODH, fixed concentration of dihydroorotate of 1.0 mM and varied concentrations of decylubiquinone from 0-0.2 mM

1.3.5.2

0.065

-

673547

N-terminally truncated DHODH, fixed concentration of dihydroorotate and varied concentrations of 2,6-dichloroindophenol from 0-0.2 mM

1.3.5.2

0.04

-

673547

N-terminally truncated DHODH, concentration of dihydroorotate varied from 0-1.0 mM at fixed concentrations of 0.1 mM decylubiquinone and 0.06 mM 2,6-dichloroindophenol

1.3.5.2

0.111

-

673547

mutant R265K

1.3.5.2

0.013

-

675315

mutant H185A

1.3.5.2

0.019

-

675315

mutant F188A

1.3.5.2

0.017

-

675315

full-length DHODH, fixed concentration of dihydroorotate of 1.0 mM and varied concentrations of decylubiquinone from 0-0.2 mM

1.3.5.2

0.042

-

673547

full-length DHODH, fixed concentration of dihydroorotate of 1.0 mM and varied concentrations of 2,6-dichloroindophenol from 0-0.2 mM

1.3.5.2

0.122

-

673547

full-length DHODH, concentration of dihydroorotate varied from 0-1.0 mM at fixed concentrations of 0.1 mM decylubiquinone and 0.06 mM 2,6-dichloroindophenol

1.3.5.2

0.108

-

673547

-

1.3.5.2

0.014

-

390929

-

1.3.5.2

0.01

-

391227

-

2 entries

DELTA22-37 mutant enzyme

1.3.5.2

0.0166

-

655723

DELTA2-37 mutant enzyme

1.3.5.2

0.0167

-

655723

DELTA2-21 mutant enzyme

1.3.5.2

0.0164

-

655723

-

1.3.5.2

0.005

-

391235

cosubstrate ubiquinone-50

1.3.5.2

0.004

-

391233

cosubstrate decylubiquinone

1.3.5.2

0.009

-

391233

pH 8.5, 70°C

1.3.98.1

0.0442

-

655517

native DHOD at 25°C

1.3.98.1

0.0259

-

676289

37°C, pH 7.0

1.3.98.1

0.03

-

676289

37°C, pH 7.0

1.3.98.1

0.071

-

676289

37°C, pH 7.0

2 entries

DHOD at 25°C

1.3.98.1

0.0243

-

676289

in the presence of 1 mM fumarate

1.3.98.1

0.0579

-

676964

in the presence of 0.5 mM fumarate

1.3.98.1

0.0472

-

676964

in the presence of 0.25 mM fumarate

1.3.98.1

0.0332

-

676964

in the presence of 0.125 mM fumarate

1.3.98.1

0.0192

-

676964

DHOD3 at 37°C

1.3.98.1

0.071

-

676289

DHOD1 and DHOD2 at 37°C

1.3.98.1

0.03

-

676289

Zn/Zn-dihydroorotase, pH 8.0

3.5.2.3

0.08

-

667595

purified recombinant enzyme, at 37°C

3.5.2.3

0.063

-

670191

-

3.5.2.3

3.03

-

652558

-

3.5.2.3

0.076

-

246634

-

2 entries

Cd/Cd-dihydroorotase, pH 8.0

3.5.2.3

0.23

-

667595

Co/Co-dihydroorotase, pH 8.0

3.5.2.3

0.7

-

667595

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

COMMENTARY

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

LITERATURE

pH 8.0, 25°C, recombinant enzyme

3.5.2.5

18.6

-

733422

References & Links

Literature References (54)

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Show Reference (54 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

209290

-

D-p-Hydroxyphenylglycine production from DL-5-p-hydroxyphenylglycine production from DL-5-p-hydroxyphenylhydantoin by Agrobacterium sp.

1990

Runser, S.; Chinski, N.; Ohleyer, E.

Appl. Microbiol. Biotechnol.

33

382-388

246634

6142052

Dihydroorotase from Escherichia coli. Purification and characterization

1984

Washabaugh, M.W.; Collins, K.D.

J. Biol. Chem.

259

3293-3298

390561

13610849

Purification and properties of diihydroorotic dehydrogenase

1958

Friedmann, H.C.; Vennesland, B.

J. Biol. Chem.

233

1398-1406

390562

13115431

Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase

1953

Lieberman, I.; Kornberg, A.

Biochim. Biophys. Acta

12

223-234

390565

-

Latent Inhibitors. Part 4. Irreversible inhibition of dihydro-orotate dehydrogenase by hydantoins derived from amino acids

1988

Buntain, I.G.; Suckling, C.J.; Wood, H.C.S.

J. Chem. Soc. Perkin Trans. I

1988

3175-3182

390568

10956027

Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis

2000

Argyrou, A.; Washabaugh, M.W.; Pickart, C.M.

Biochemistry

39

10373-10384

390569

11188687

Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster

2000

Rowland, P.; Norager, S.; Jensen, K.F.; Larsen, S.

Structure

8

1227-1238

390915

9655329

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymic function

1998

Rowland, P.; Bjornberg, O.; Nielsen, F.S.; Jensen, K.F.; Larsen, S.

Protein Sci.

7

1269-1279

390916

8732756

Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme

1996

Nielsen, F.S.; Rowland, P.; Larsen, S.; Jensen, K.F.

Protein Sci.

5

852-856

390917

8021180

Two different dihydroorotate dehydrogenases in Lactococcus lactis

1994

Andersen, P.S.; Jansen, P.J.G.; Hammer, K.

J. Bacteriol.

176

3975-3982

390919

11284694

Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies

2001

Palfey, B.A.; Bjoernberg, O.; Jensen, K.F.

Biochemistry

40

4381-4390

390925

8852433

Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria

1996

Loeffler, M.; Becker, C.; Wegerle, E.; Schuster, G.

Histochem. Cell Biol.

105

119-128

390926

9693067

Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase

1998

Bader, B.; Knecht, W.; Fries, M.; Loffler, M.

Protein Expr. Purif.

13

414-422

390927

10871048

Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors

2000

Jordan, D.B.; Bisaha, J.J.; Picollelli, M.A.

Arch. Biochem. Biophys.

378

84-92

390928

10545205

Biochemical characterization of the heteromeric Bacillus subtilis dihydroorotate dehydrogenase and its isolated subunits

1999

Kahler, A.E.; Nielsen, F.S.; Switzer, R.L.

Arch. Biochem. Biophys.

371

191-201

390929

7727509

Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite

1995

Krungkrai, J.

Biochim. Biophys. Acta

1243

351-360

390930

10775458

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism

2000

Marcinkeviciene, J.; Jiang, W.; Locke, G.; Kopcho, L.M.; Rogers, M.J.; Copeland, R.A.

Arch. Biochem. Biophys.

377

178-186

391221

216313

Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme

1978

Forman, H.J.; Kennedy, J.

Arch. Biochem. Biophys.

191

23-31

391222

199900

Purification of the primary dihydroorotate dehydrogenase (oxidase) from rat liver mitochondria

1977

Forman, H.J.; Kennedy, J.

Prep. Biochem.

7

345-355

391223

211392

Dihydroorotate dehydrogenase (Neurospora)

1978

Miller, R.W.

Methods Enzymol.

51

63-69

391224

3733756

Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase [published erratum appears in J Biol Chem 1987 Nov 5;262(31):15322]

1986

Hines, V.; Keys, L.D.; Johnston, M.

J. Biol. Chem.

261

11386-11392

391226

2540819

Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase

1989

Hines, V.; Johnston, M.

Biochemistry

28

1222-1226

391227

211391

Dihydroorotate dehydrogenase (Escherichia coli)

1978

Karibian, D.

Methods Enzymol.

51

58-63

391229

-

Properties and subcellular localization of dihydroorotate dehydrogenase in cells of tomato suspension culture

1986

Miersch, J.; Krauss, G.J.; Metzger, U.

J. Plant Physiol.

122

55-66

391233

8925840

Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

1996

Knecht, W.; Bergjohann, U.; Gonski, S.; Kirschbaum, B.; Loffler, M.

Eur. J. Biochem.

240

292-301

391235

9179295

Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells

1997

Knecht, w.; Altekruse, D.; Rotgeri, A.; Gonski, S.; Loffler, M.

Protein Expr. Purif.

10

89-99

391241

8573583

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

1996

Davis, J.P.; Cain, G.A.; Pitts, W.J.; Magolda, R.L.; Copeland, R.A.

Biochemistry

35

1270-1273

391242

10658902

Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid

2000

Knecht, W.; Henseling, J.; Loffler, M.

Chem. Biol. Interact.

124

61-76

489712

692383

Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)

1978

Jones, M.E.; Kavipurapu, P.R.; Traut, T.W.

Methods Enzymol.

51

155-167

652558

15381710

Aquifex aeolicus dihydroorotase: association with aspartate transcarbamoylase switches on catalytic activity

2004

Ahuja, A.; Purcarea, C.; Ebert, R.; Sadecki, S.; Guy, H.I.; Evans, D.R.

J. Biol. Chem.

279

53136-53144

654759

15157083

Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy

2004

Mohsen, A.W.; Rigby, S.E.; Jensen, K.F.; Munro, A.W.; Scrutton, N.S.

Biochemistry

43

6498-6510

655517

12072960

A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus

2002

Sorensen, G.; Dandanell, G.

Extremophiles

6

245-251

655559

12372626

Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes

2002

Ullrich, A.; Knecht, W.; Piskur, J.; Loffler, M.

FEBS Lett.

529

346-350

655723

12213251

Drosophila melanogaster dihydroorotate dehydrogenase: the N-terminus is important for biological function in vivo but not for catalytic properties in vitro

2002

Loffler, M.; Knecht, W.; Rawls, J.; Ullrich, A.; Dietz, C.

Insect Biochem. Mol. Biol.

32

1159-1169

656148

12732650

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function

2003

Norager, S.; Arent, S.; Bjornberg, O.; Ottosen, M.; Lo Leggio, L.; Jensen, K.F.; Larsen, S.

J. Biol. Chem.

278

28812-28822

656747

12106873

Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi

2002

Takashima, E.; Inaoka, D.K.; Osanai, A.; Nara, T.; Odaka, M.; Aoki, T.; Inaka, K.; Harada, S.; Kita, K.

Mol. Biochem. Parasitol.

122

189-200

667595

15610022

Mechanism of the dihydroorotase reaction

2004

Porter, T.N.; Li, Y.; Raushel, F.M.

Biochemistry

43

16285-16292

670191

16621066

Cloning and preliminary characterization of the dihydroorotase from Toxoplasma gondii

2006

Robles Lopez, S.M.; Hortua Triana, M.A.; Zimmermann, B.H.

Mol. Biochem. Parasitol.

148

93-98

671050

16510978

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

2006

Hurt, D.E.; Widom, J.; Clardy, J.

Acta Crystallogr. Sect. D

62

312-323

672109

17154530

Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases

2006

Fagan, R.L.; Nelson, M.N.; Pagano, P.M.; Palfey, B.A.

Biochemistry

45

14926-14932

673547

16774642

Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans

2006

Zameitat, E.; Gojkovic, Z.; Knecht, W.; Piskur, J.; Loeffler, M.

FEBS J.

273

3183-3191

675294

16480261

Dual binding mode of a novel series of DHODH inhibitors

2006

Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J.

J. Med. Chem.

49

1239-1247

675315

17228860

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase

2007

Heikkilä, T.; Ramsey, C.; Davies, M.; Galtier, C.; Stead, A.M.W.; Johnson, A.P.; Fishwick, C.W.G.; Boa, A.N.; McConkey, G.A.

J. Med. Chem.

50

186-191

675478

15696374

The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions

2005

Annoura, T.; Nara, T.; Makiuchi, T.; Hashimoto, T.; Aoki, T.

J. Mol. Evol.

60

113-127

675614

17004840

Hydrogen bonding pathways in human dihydroorotate dehydrogenase

2006

Small, Y.A.; Guallar, V.; Soudackov, A.V.; Hammes-Schiffer, S.

J. Phys. Chem. B

110

19704-19710

676289

16172019

Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms

2006

Sariego, I.; Annoura, T.; Nara, T.; Hashimoto, M.; Tsubouchi, A.; Iizumi, K.; Makiuchi, T.; Murata, E.; Kita, K.; Aoki, T.

Parasitol. Int.

55

11-16

676859

16585513

Single-molecule kinetics reveals signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysis

2006

Shi, J.; Dertouzos, J.; Gafni, A.; Steel, D.; Palfey, B.A.

Proc. Natl. Acad. Sci. USA

103

5775-5780

676964

16600626

Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase

2006

Feliciano, P.R.; Cordeiro, A.T.; Costa-Filho, A.J.; Nonato, M.C.

Protein Expr. Purif.

48

98-103

684848

17475213

Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens

2007

Annoura, T.; Sariego, I.; Nara, T.; Makiuchi, T.; Fujimura, T.; Taka, H.; Mineki, R.; Murayama, K.; Aoki, T.

Biochem. Biophys. Res. Commun.

358

253-258

685158

17444658

Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

2007

Wolfe, A.E.; Thymark, M.; Gattis, S.G.; Fagan, R.L.; Hu, Y.C.; Johansson, E.; Arent, S.; Larsen, S.; Palfey, B.A.

Biochemistry

46

5741-5753

696249

18225919

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

2008

Malmquist, N.A.; Gujjar, R.; Rathod, P.K.; Phillips, M.A.

Biochemistry

47

2466-2475

698938

19640844

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds

2009

Deng, X.; Gujjar, R.; El Mazouni, F.; Kaminsky, W.; Malmquist, N.A.; Goldsmith, E.J.; Rathod, P.K.; Phillips, M.A.

J. Biol. Chem.

284

26999-27009

733422

24418229

Allantoinase and dihydroorotase binding and inhibition by flavonols and the substrates of cyclic amidohydrolases

2014

Peng, W.F.; Huang, C.Y.

Biochimie

101

113-122

758121

25993634

Inhibition of a putative dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by flavonoids and substrates of cyclic amidohydrolases

2015

Huang, C.Y.

PLoS ONE

10

e0127634

Links to other databases for dihydroorotate

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