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Ligand 5-Carboxymethyl-2-hydroxymuconate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 5-Carboxymethyl-2-hydroxymuconate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.3.10

5-carboxymethyl-2-hydroxymuconate = ?

2920, 2921, 2918, 2917

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.60

5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH

288297, 288299, 288300, 288301, 288298, 288303, 288040

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.3.3.10

5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate

2918, 2919, 2920, 2917, 2921

-

5.3.3.10

5-carboxymethyl-2-hydroxymuconate = ?

2920, 2921, 2918, 2917

-

5.3.3.10

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.60

5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH

288297, 288299, 288300, 288301, 288298, 288303, 288040

-

1.2.1.60

5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NADP+ = 5-carboxymethyl-2-hydroxymuconate + NADPH

288300, 288301, 288298

-

1.2.1.60

2 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.3.3.10

0.28

-

-

2917

5.3.3.10

0.3

-

-

2918

5.3.3.10

2 entries

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2917

-

Isomerase and decarboxylase activities in the 4-hydroxyphenylacetate catabolic pathway of Pseudomonas putida

1985

Martin, M.L.; Garrido-Pertierra, A.

Z. Naturforsch. C

40

503-508

2918

7026235

Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli

1981

Garrido-Pertierra, A.; Cooper, R.A.

Eur. J. Biochem.

117

581-584

2919

2693745

Preliminary crystallographic analysis of 5-carboxymethyl-2-hydroxymuconate isomerase from Escherichia coli

1989

Wigley, D.B.; Roper, D.I.; Cooper, R.A.

J. Mol. Biol.

210

881-882

2920

2194841

Purification, some properties and nucleotide sequence of 5-carboxymethyl-2-hydroxymuconate isomerase of Escherichia coli

1990

Roper, D.I.; Cooper, R.A.

FEBS Lett.

266

63-66

2921

-

Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications

1995

Johnson, W.H.; Hajipour, G.; Whitman, C.P.

J. Am. Chem. Soc.

117

8719-8726

288040

20216

The catabolism of L-tyrosine by an Arthrobacter sp.

1977

Blakley, E.R.

Can. J. Microbiol.

23

1128-1139

288297

2656390

5-Carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenases of Escherichia coli C and Klebsiella pneumoniae M5a1 show very high N-terminal sequence homology

1989

Fawcett, T.; Garrido-Pertierra, A.; Cooper, R.A.

FEMS Microbiol. Lett.

57

307-312

288298

-

Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Pseudomonas putida

1986

Alonso, J.M.; Garrido-Pertierra, A.

Biochem. Cell Biol.

64

1288-1293

288299

3089331

Kinetic properties of 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase from Escherichia coli

1986

Alonso, J.M.; Garrido-Pertierra, A.

Biochimie

68

731-737

288300

6756482

Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli

1982

Alonso, J.M.; Garrido-Pertierra, A.

Biochim. Biophys. Acta

719

165-167

288301

6995433

Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli

1980

Cooper, R.A.; Skinner, M.A.

J. Bacteriol.

143

302-306

288303

6895079

Control of meta-cleavage degradation of 4-hydroxyphenylacetate in Pseudomonas putida

1981

Barbour, M.G.; Bayly, R.C.

J. Bacteriol.

147

844-850

Links to other databases for 5-Carboxymethyl-2-hydroxymuconate

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