Ligand 2-methylbutanoate

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Basic Ligand Information

Molecular Structure
Picture of 2-methylbutanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10O2
2-methylbutanoate
WLAMNBDJUVNPJU-UHFFFAOYSA-M
Synonyms:
2-Methylbutanoic acid, 2-Methylbutenoic acid, 2-methylbutyrate, 2-methylbutyric acid


Show all pahtways known for Show all BRENDA pathways known for 2-methylbutanoate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 2-methylbutanoate = ADP + 2-methylbutanoyl phosphate
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ATP + 2-methylbutyrate = ADP + 2-methylbutyryl phosphate
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ATP + 2-methylbutyrate = ADP + 2-methylbutyryl phosphate
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ATP + 2-methylbutyrate + CoA = ADP + phosphate + 2-methylbutyryl-CoA
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ATP + 2-methylbutyrate + CoA = AMP + diphosphate + 2-methylbutyryl-CoA
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ATP + 2-methylbutyrate + CoA = ADP + phosphate + 2-methylbutyryl-CoA
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-methlybutyraldehyde + NADP+ + H2O = 2-methylbutanoate + NADPH + H+
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2-methylbutyraldehyde + NAD+ + H2O = 2-methylbutyrate + NADH + H+
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2-methylbutyraldehyde + H2O + oxidized benzyl viologen = 2-methylbutyrate + reduced benzyl viologen + H+
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2-methylbutyronitrile + H2O = 2-methylbutyric acid + NH3
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2,4-diketo-5-methylheptanoate + H2O = pyruvate + 2-methylbutanoate
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5.22 mM, competitive inhibitor, 60% inhibition at pH 7.5, 54% inhibition at pH 7.0
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.58
-
pH 7.5, 55°C

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10.8
-
pH 7.5, 30°C
10.8
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at pH 7.5 and 30°C
8.92
-
pH 7.5, 55°C

References & Links

Links to other databases for 2-methylbutanoate

ChEBI
PubChem
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PubChem