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Ligand dTDP-beta-L-vancosamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.322

dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin

721585, 724268

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.322

dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin = dTDP + vancomycin

736938

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2.4.1.322

dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin

721585, 727292, 727659, 724268

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2.4.1.322

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

721585

11294642

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides

2001

Losey, H.C.; Peczuh, M.W.; Chen, Z.; Eggert, U.S.; Dong, S.D.; Pelczer, I.; Kahne, D.; Walsh, C.T.

Biochemistry

40

4745-4755

724268

15122882

Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

2004

Mulichak, A.M.; Lu, W.; Losey, H.C.; Walsh, C.T.; Garavito, R.M.

Biochemistry

43

5170-5180

727292

12498883

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides

2002

Losey, H.C.; Jiang, J.; Biggins, J.B.; Oberthuer, M.; Ye, X.Y.; Dong, S.D.; Kahne, D.; Thorson, J.S.; Walsh, C.T.

Chem. Biol.

9

1305-1314

727659

16045364

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases

2005

Oberthuer, M.; Leimkuhler, C.; Kruger, R.G.; Lu, W.; Walsh, C.T.; Kahne, D.

J. Am. Chem. Soc.

127

10747-10752

736938

24954524

Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate

2014

Nakayama, A.; Okano, A.; Feng, Y.; Collins, J.C.; Collins, K.C.; Walsh, C.T.; Boger, D.L.

Org. Lett.

16

3572-3575

Links to other databases for dTDP-beta-L-vancosamine

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Show Links (1 entry)

ChEBI

PubChem

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