Ligand (10E,12Z)-octadeca-10,12-dienoic acid

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Basic Ligand Information

Molecular Structure
Picture of (10E,12Z)-octadeca-10,12-dienoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H32O2
(10E,12Z)-octadeca-10,12-dienoic acid
GKJZMAHZJGSBKD-NMMTYZSQSA-N
Synonyms:
(10E,12Z)-octadec-10,12-dienoic acid, (10E,12Z)-octadecadienoic acid, 10-trans,12-cis-linoleic acid, trans-10,cis-12 conjugated linoleic acid, trans-10,cis-12-linoleic acid, trans10, cis12-conjugated linoleic acid

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-10,cis-12-linoleic acid + H2O2 = 12,13-epoxy-10-octadecenoic acid
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
reduces expression of FMO3 by 95%, and inhibits activity of hepatic microsomal FMO by 40% and of isozyme FMO3 activity by 67%, the compound has a strong effect on hepatic fatyy acid oxidation, overview
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more potent inhibitor than (9Z,11E)-octadec-9,11-dienoic acid
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non-competitive inhibition mechanism
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.815
-
pH 6.0, 40°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.14
-
pH 7.5, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.08
-
pH 7.5, 37°C

References & Links

Links to other databases for (10E,12Z)-octadeca-10,12-dienoic acid

ChEBI
PubChem
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PubChem