Ligand vitamin B12

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Basic Ligand Information

Molecular Structure
Picture of vitamin B12 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C63H90CoN14O14P
vitamin B12
RMRCNWBMXRMIRW-WYVZQNDMSA-L
Synonyms:
CN-B12, cyano-cobalamin, cyanocob(III)alamin, cyanocobalamin, vitamin B12[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADPH + cyanocob(III)alamin = NADP+ + cob(I)alamin + cyanide
show the reaction diagram
-
cyano-cobalamin + H2O = hydroxyl-cobalamin + cyanide
show the reaction diagram
-
ATP + H2O + vitamin B12/out = ADP + phosphate + vitamin B12/in
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NADPH + cyanocob(III)alamin = NADP+ + cob(I)alamin + cyanide
show the reaction diagram
-
cyanocobalamin + H2O = adenosylcobyric acid + ?
show the reaction diagram
-
cyano-cobalamin + H2O = hydroxyl-cobalamin + cyanide
show the reaction diagram
-
ATP + H2O + vitamin B12/out = ADP + phosphate + vitamin B12/in
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Cofactor/Cosubstrate (28 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.0033 mM, maximal activity
-
required
-

Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
tetrachloroethene dehalogenase formation in fumarate-grown cells is influenced by vitamin B12
-
stimulates
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
a 250fold excess of unlabeled CN-Cbl inhibits the uptake of the radiolabeled substrate almost completely
-

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0426
-
-
0.0264
-
-

References & Links

Links to other databases for vitamin B12

ChEBI
PubChem
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PubChem