Ligand tRNAMet

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Basic Ligand Information

Molecular Structure

C₂₈H₃₇N₁₁O₂₁P₃R

tRNAMet

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Synonyms:

5'-dephospho-RNA (n-1 nucleotides), ribosomal RNA, rRNA, t-RNALeu, tRNA(Ala), tRNA(Arg), tRNA(Asn), tRNA(Asp), tRNA(Cys), tRNA(Gln), tRNA(Glu), tRNA(Gly), tRNA(His), tRNA(Ile), tRNA(Leu), tRNA(Lys), tRNA(lys)), tRNA(Met), tRNA(Phe), tRNA(Pro), tRNA(Ser), tRNA(Thr), tRNA(Trp), tRNA(Tyr), tRNA(Val), tRNA-CCA-3', tRNA-Gly, tRNA-His, tRNA-Leu, tRNA-Met, tRNA-N, tRNA-Phe, tRNA-Tyr, tRNA-Val, tRNA1Glu, tRNA1Gly, tRNA2Glu, tRNA2Gly, tRNAAla, tRNAArg, tRNAAsn, tRNAAsp, tRNAAsx, tRNACys, tRNAGln, tRNAGlu, tRNAGlx, tRNAGly, tRNAguanine, tRNAHis, tRNAHisII, tRNAIle, tRNALys, tRNAPhe, tRNAPro, tRNAPyl, tRNAqueuine, tRNA queuine, tRNASer, tRNAThr, tRNATrp, tRNATyr, tRNAVal

Related pathways

BRENDA

alanine metabolism, arginine metabolism, aspartate and asparagine metabolism, cysteine metabolism, glutamate and glutamine metabolism

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MetaCyc

3-thia-L-glutamate biosynthesis, Arg/N-end rule pathway (eukaryotic), dehydrophos biosynthesis, glutaminyl-tRNAgln biosynthesis via transamidation, L-asparagine biosynthesis III (tRNA-dependent)

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Show all BRENDA pathways known for tRNAMet

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (82 results)

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1.2.1.70

L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+

742161, 742025, 742876, 741545, 762968, 763344, 763419, 763567, 763580, 763646

2.1.1.B140

tRNAHis + S-adenosyl-L-methionine = methylated tRNAHis + S-adenosyl-L-homocysteine

762054

2.3.2.37

ATP + Asp + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp

763648

2.3.2.B18

ATP + glycine + tRNAGly = AMP + diphosphate + L-glycyl-tRNAGly

rRNA + H2O = ?

rRNA + H2O = ?

646907, 646920, 646910, 646923, 646924, 646916, 646928, 646902, 646922, 646927, 646896, 646901, 646904, 646930, 646897, 646912, 646908, 646314, 646900, 646913, 646915, 646917, 646919, 646929, 646925, 646894, 646895, 646906, 646899, 646903, 646911, 646905, 646909, 646926, 646914, 646898, 646921, 666505, 664089, 666978, 665864, 731786, 731947, 732071, 732120, 732064, 732343, 732879, 732890, 732949, 732952, 731188, 731333, 731351, 731509, 731676, 732953

4.6.1.19

rRNA + H2O = ?

771479

4.6.1.23

rRNA + H2O = ?

646298, 646299, 646300, 646301, 646302, 646303, 646304, 646305, 646306, 646307, 646308, 646309, 646310, 646311, 646312, 646313, 646314, 646315, 646316, 646317, 646318, 646319, 646320, 646321, 772072

ATP + L-cysteine + tRNACys = AMP + diphosphate + L-cysteinyl-tRNACys

653867, 649098, 652821, 650423, 650990, 652909, 653662, 672180, 675395, 675435, 746197, 745862, 746259, 745531, 746416, 765967, 767101, 767099

ATP + L-asparagine + tRNAAsn = AMP + diphosphate + L-asparaginyl-tRNAAsn

653175, 653372, 653373, 650960, 715924, 727971, 728271, 716420, 746169, 746194, 745056, 745186, 746380, 766741, 767463, 766146, 767936

ATP + L-pyrrolysine + tRNAPyl = AMP + diphosphate + L-pyrrolysyl-tRNAPyl

676083, 676882, 671091, 673677, 673691, 676141, 676218, 676766, 690734, 693638, 727522, 727925, 728143, 726549, 727315, 727678, 727524, 727525, 744388, 745929

ATP + L-leucine + tRNAIle = AMP + diphosphate + L-leucyl-tRNALeu

744968

6.1.1.5

ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle

650560, 651904, 650527, 652205, 653886, 652566, 652415, 651903, 651905, 650559, 652046, 650564, 449, 672235, 675256, 675388, 706028, 704642, 705210, 715519, 728395, 727946, 746476, 745675, 744324, 744920, 745362

ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal

653865, 650777, 653871, 650122, 650085, 653390, 652179, 674764, 726908, 727894, 727910, 744977, 744659, 745020

6.1.1.B3

ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp

727254, 746385, 746388

In Vivo Product in Enzyme-catalyzed Reactions (68 results)

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1.2.1.70

L-glutamyl-tRNAGlu + NADPH + H+ = L-glutamate 1-semialdehyde + NADP+ + tRNAGlu

2.3.2.10

2 entries

2.3.2.11

L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol

2.3.2.12

2 entries

2.3.2.18

MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + glycyl-tRNAGly = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-penta-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + tRNAGly

ergosterol + L-glycyl-tRNAGly = ergosteryl-3beta-O-glycine + tRNAGly

2.3.2.B19

glycyl-tRNAGly + ergosterol = tRNAGly + 1-(ergostan-3beta-yl)-glycine

2.3.2.B22

L-lysyl-tRNALys + diacylglycerol = tRNALys + lysyl-diacylglycerol

Substrate in Enzyme-catalyzed Reactions (347 results)

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1.2.1.70

L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+

742161, 742025, 742876, 741545, 762968, 763344, 763419, 763567, 763580, 763646

2.1.1.B140

tRNAHis + S-adenosyl-L-methionine = methylated tRNAHis + S-adenosyl-L-homocysteine

ATP + glycine + tRNAGly = AMP + diphosphate + L-glycyl-tRNAGly

tRNAguanine + 7-cyano-7-deazaguanine = ?

S-adenosyl-L-methionine + tRNAPhe = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl) uridine

638436

2.7.7.19

ATP + rRNA = diphosphate + ?

723759

2.7.7.72

tRNACys + 2 CTP + ATP = tRNACys with 3'-CCA end + 3 diphosphate

rRNA + H2O = ?

tRNATyr + H2O = ?

ribosomal RNA + H2O = smaller precursor rRNA

134345, 134354, 134334, 134340, 134360, 134357, 134361, 134339, 134364

3.1.27.8

rRNA + H2O = ?

24268

3.2.2.22

rRNA + H2O = ?

646907, 646920, 646910, 646923, 646924, 646916, 646928, 646902, 646922, 646927, 646896, 646901, 646904, 646930, 646898, 646921, 646897, 646912, 646908, 646314, 646900, 646913, 646915, 646917, 646919, 646929, 646925, 646895, 646906, 646894, 646903, 646911, 646905, 646909, 646926, 646914, 646899, 666505, 664089, 666978, 665864, 666993, 666379, 665623, 664414, 684058, 698309, 698877, 699064, 699394, 700505, 696491, 714904, 715587, 731786, 731947, 732071, 732120, 732064, 732343, 732879, 732890, 732949, 732952, 731188, 731333, 731351, 731509, 731676, 732953

rRNA + H2O = ?

rRNA + H2O = ?

646298, 646299, 646300, 646301, 646302, 646303, 646304, 646305, 646306, 646307, 646308, 646309, 646310, 646311, 646312, 646313, 646314, 646315, 646316, 646317, 646318, 646319, 646320, 646321, 772072

ATP + L-leucine + tRNAIle = AMP + diphosphate + L-leucyl-tRNALeu

ATP + L-glutamate + tRNAAsp = AMP + diphosphate + L-glutamyl-tRNAAsp

721752, 660375, 727254, 746385, 746388

6.3.5.7

ATP + L-glutamate + tRNAGlu = AMP + diphosphate + L-glutamyl-tRNAGlu

728668

Product in Enzyme-catalyzed Reactions (198 results)

L-alanyl-tRNAAla + phosphatidylglycerol = tRNAAla + 3-O-L-alanyl-1-O-phosphatidylglycerol

487794, -

2.3.2.12

5 entries

2.3.2.16

glycyl-tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine = tRNAGly + N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine

ergosterol + L-glycyl-tRNAGly = ergosteryl-3beta-O-glycine + tRNAGly

2.3.2.B19

glycyl-tRNAGly + ergosterol = tRNAGly + 1-(ergostan-3beta-yl)-glycine

2.3.2.B20

L-alanyl-tRNAAla(UGC) + L-glutamyl-tRNAGlu = tRNAAla(UGC) + tRNAGlu + cyclo(L-alanyl-L-glutamyl)

2.3.2.B21

2 entries

2.3.2.B22

L-lysyl-tRNALys + diacylglycerol = tRNALys + lysyl-diacylglycerol

2.3.2.B23

11 entries

2.4.2.29

guanine + tRNAguanine = tRNAguanine + guanine

2.4.2.64

tRNAqueuine + guanine = tRNAguanine + queuine

pre-tRNAArg + H2O = tRNAArg + 3'-leader of tRNA

AMP + diphosphate + L-tyrosyl-tRNATyr = ATP + L-tyrosine + tRNATyr

6.1.1.10

AMP + diphosphate + L-methionyl-tRNAMet = ATP + L-methionine + tRNAMet

6.1.1.11

AMP + diphosphate + L-seryl-tRNASer = ATP + L-serine + tRNASer

6.1.1.16

AMP + diphosphate + L-cysteinyl-tRNACys = ATP + L-cysteine + tRNACys

6.1.1.3

AMP + diphosphate + L-threonyl-tRNAThr = ATP + L-threonine + tRNAThr

Activator in Enzyme-catalyzed Reactions (6 results)

enzyme CrhC is stimulated most efficiently by rRNA, e.g. by 16S and 23S rRNA from Anabaena or Escherichia coli

774758

5.6.2.7

activates the ATPase activity of DbpA by promoting a conformational change after ATP binding that is associated with hydrolysis

693631

6.1.1.10

required by the nucleolar located enzyme

652598

6.1.1.11

2 entries

Inhibitor in Enzyme-catalyzed Reactions (6 results)

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2.1.1.35

inhibits binding of 16S rRNA to RUMT

tRNALys from Escherichia coli

648112

3.1.13.1

weak inhibitor of T4 mRNA-degradation

134052

3.1.22.1

specific competitive inhibition

134308

6.1.1.1

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (403 results)

0.19

pH 7.2, 37°C, wild-type tRNAPyl

0.04

pH 7.2, 37°C

728668

K_M Value (524 results)

0.0029

pH 7.2, 37°C, wild-type tRNAPyl

0.00015

pH 7.2, 37°C

660375

6.3.5.7

0.00361

pH 7.2, 37°C

728668

K_i Value (1 result)

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3.1.1.29

0.00005

pH 7.5, 50°C, tRNALys from Escherichia coli

648112

References & Links

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Show Reference (1524 entries)

Links to other databases for tRNAMet

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Ligand tRNAMet

Basic Ligand Information

Related pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (82 results)

In Vivo Product in Enzyme-catalyzed Reactions (68 results)

Substrate in Enzyme-catalyzed Reactions (347 results)

Product in Enzyme-catalyzed Reactions (198 results)

Activator in Enzyme-catalyzed Reactions (6 results)

Inhibitor in Enzyme-catalyzed Reactions (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (403 results)

KM Value (524 results)

Ki Value (1 result)

References & Links

Literature References (1524)

Links to other databases for tRNAMet

k_cat Value (Turnover Number) (403 results)

K_M Value (524 results)

K_i Value (1 result)