Ligand (S)-6-hydroxywarfarin
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Basic Ligand Information
Molecular Structure

C19H16O5
(S)-6-hydroxywarfarin
IQWPEJBUOJQPDE-AWEZNQCLSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate = (S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
Enzyme Kinetic Parameters
KM Value (1 result)
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0.36
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isoform UGT1A10, pH 7.6, 37°C
References & Links
Literature References (1)
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Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases
2012
Bratton, S.M.; Mosher, C.M.; Khallouki, F.; Finel, M.; Court, M.H.; Moran, J.H.; Radominska-Pandya, A.
J. Pharmacol. Exp. Ther.
340
46-55
Links to other databases for (S)-6-hydroxywarfarin