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Ligand ginsenoside Rg1

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for ginsenoside Rg1

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.192

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

753042

-

3.2.1.194

ginsenoside Rg1 + H2O = ginsenoside F1 + D-glucose

753334, 754799, 752583

-

3.2.1.194

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

754213, 753042

-

3.2.1.194

2 entries

3.2.1.195

ginsenoside Rg1 + H2O = protopanaxatriol + 2 D-glucose

753334

-

3.2.1.B23

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

753334

-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

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Show Natural Product (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.366

UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

0

-

2.4.1.367

UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

0

-

3.2.1.194

ginsenoside Re + H2O = ginsenoside Rg1 + L-rhamnose

0

-

3.2.1.194

notoginsenoside R1 + H2O = ginsenoside Rg1 + D-xylose

0

-

3.2.1.194

2 entries

Substrate in Enzyme-catalyzed Reactions (8 results)

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Show Substrate (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.38

UDP-galactose + ginsenoside Rg1 = UDP + beta-D-galactosyl-1,4-ginsenoside Rg1

675468

-

2.4.1.90

UDP-galactose + ginsenoside Rg1 = ?

675468

-

3.2.1.192

ginsenoside Rg1 + H2O = ginsenoside 20(S)-Rh1 + D-glucopyranose

754332, 754434

-

3.2.1.192

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

753042

-

3.2.1.194

ginsenoside Rg1 + H2O = ginsenoside F1 + D-glucose

753334, 754799, 752583, 722934, 723613

-

3.2.1.194

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

754213, 753042

-

3.2.1.192

2 entries

3.2.1.194

2 entries

3.2.1.195

ginsenoside Rg1 + H2O = protopanaxatriol + 2 D-glucose

753334

-

3.2.1.B23

ginsenoside Rg1 + H2O = ginsenoside Rh1 + D-glucose

753334

-

Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.366

UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

0

-

2.4.1.366

UDP-alpha-D-glucose + ginsenoside F1 = UDP + ginsenoside Rg1

0

-

2.4.1.366

2 entries

2.4.1.367

UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1

0

-

3.2.1.194

ginsenoside R1 + H2O = ginsenoside Rg1 + D-xylose

0

-

3.2.1.194

ginsenoside Re + H2O = ginsenoside Rg1 + L-rhamnose

0

-

3.2.1.194

notoginsenoside R1 + H2O = ginsenoside Rg1 + D-xylose

0

-

3.2.1.21

ginsenoside R1 + H2O = ginsenoside Rg1 + D-xylose

0

-

3.2.1.21

ginsenoside Re + H2O = ginsenoside Rg1 + L-rhamnose

0

-

3.2.1.194

3 entries

3.2.1.21

2 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.11.22

noncompetitive inhibition

723745

-

3.1.3.16

from Panax ginseng roots, Rg1 alleviates left ventricular hypertrophy induced by abdominal aorta coarctation, and the protection appears to be due, at least in part, to its inhibitory effects on calcineurin and MAP kinase signaling pathways, overview

708398

-

6.2.1.45

inhibit ubiquitin-activating enzyme, from Panax ginseng roots, a traditional herbal medicine or food, causes 89.2% inhibition at 0.05 mM

734395

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.2.1.194

5.75

-

recombinant enzyme, pH 6.5, 30°C

754213

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.194

6.61

-

recombinant enzyme, pH 6.5, 30°C

754213

3.2.1.194

7.63

-

pH 6, 40°C

723613

3.2.1.194

2 entries

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.11.22

0.00785

-

pH 7.5, 37°C

723745

6.2.1.45

0.0035

-

recombinant enzyme, pH 7.6, 37°C

734395

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

675468

-

beta-1,4-Galactosyltransferase-catalyzed glycosylation of sugar derivatives: Modulation of the enzyme activity by alpha-lactalbumin, immobilization and solvent tolerance

2006

Pisvejcova, A.; Rossi, C.; Husakova, L.; Kren, V.; Riva, S.; Monti, D.

J. Mol. Catal. B

39

98-104

708398

19347983

Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings

2009

Deng, J.; Lv, X.T.; Wu, Q.; Huang, X.N.

Eur. J. Pharmacol.

608

42-47

722934

22031031

A novel ginsenosidase from an Aspergillus strain hydrolyzing 6-O-multi-glycosides of protopanaxatriol-type ginsenosides, named ginsenosidase type IV

2011

Wang, D.M.; Yu, H.S.; Song, J.G.; Xu, Y.F.; Liu, C.Y.; Jin, F.X.

J. Microbiol. Biotechnol.

21

1057-1063

723613

-

Enzyme kinetics of ginsenosidase type IV hydrolyzing 6-O-multi-glycosides of protopanaxatriol type ginsenosides

2012

Wang, D.M.; Yu, H.S.; Song, J.G.; Xu, Y.F.; Jin, F.X.

Proc. Biochem.

47

133-138

723745

23592201

Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent kinase 5/p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry

2013

Chen, N.; Yang, H.; Niu, J.; Liu, S.

Rapid Commun. Mass Spectrom.

27

985-992

734395

-

The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity

2014

Chang, T.; Huang, Y.; Ou, Y.

J. Funct. Foods

7

462-470

752583

25820645

An amino acid at position 512 in beta-glucosidase from Clavibacter michiganensis determines the regioselectivity for hydrolyzing gypenoside XVII

2015

Shin, K.C.; Hong, S.H.; Seo, M.J.; Oh, D.K.

Appl. Microbiol. Biotechnol.

99

7987-7996

753042

-

Enzymatic transformation of ginseng leaf saponin by recombinant beta-glucosidase (bgp1) and its efficacy in an adipocyte cell line

2016

Huq, M.; Siraj, F.; Kim, Y.; Yang, D.

Biotechnol. Appl. Biochem.

63

532-538

753334

26383974

Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides

2016

Shin, K.; Oh, D.

Crit. Rev. Biotechnol.

36

1036-1049

754213

25457989

Substrate specificity of beta-glucosidase from Gordonia terrae for ginsenosides and its application in the production of ginsenosides Rg3, Rg2, and Rh1 from ginseng root extract

2015

Shin, K.; Lee, H.; Oh, D.

J. Biosci. Bioeng.

119

497-504

754332

25838236

Overexpression and characterization of a Ca2+ activated thermostable beta-glucosidase with high ginsenoside Rb1 to ginsenoside 20(S)-Rg3 bioconversion productivity

2015

Xie, J.; Zhao, D.; Zhao, L.; Pei, J.; Xiao, W.; Ding, G.; Wang, Z.

J. Ind. Microbiol. Biotechnol.

42

839-850

754434

-

Enzymatic transformation of ginsenoside Rb1 to ginsenoside 20(S)-Rg3 by GH3 beta-glucosidase from Thermotoga thermarum DSM 5069 T

2015

Pei, J.; Xie, J.; Yin, R.; Zhao, L.; Ding, G.; Wang, Z.; Xiao, W.

J. Mol. Catal. B

113

104-109

754799

28534845

Enhanced production of gypenoside LXXV using a novel ginsenoside-transforming beta-glucosidase from ginseng-cultivating soil bacteria and its anti-cancer property

2017

Cui, C.; Kim, D.; Jung, S.; Kim, S.; Im, W.

Molecules

22

844-858

Links to other databases for ginsenoside Rg1

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Show Links (1 entry)

ChEBI

PubChem