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Ligand 2-deoxy-scyllo-inosose

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 2-deoxy-scyllo-inosose

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.100

L-glutamine + 2-deoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxy-scyllo-inosamine

663004, 640131, 719670, 672584, 722025, 723736

-

2.6.1.50

2-deoxy-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-ketoglutaramate

672584

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.3.124

D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.100

L-glutamine + 2-deoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxy-scyllo-inosamine

663004, 640131, 719670, 672584, 722025, 723736

-

2.6.1.50

2-deoxy-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-ketoglutaramate

663004, 672584

-

2.6.1.50

2-deoxy-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate

661375, 661949

-

2.6.1.50

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.3.124

D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate

0

-

Enzyme Kinetic Parameters

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

640131

12546424

First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics: genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inose aminotransferase genes

2002

Tamegai, H.; Eguchi, T.; Kakinuma, K.

J. Antibiot.

55

1016-1018

661375

14969406

An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius

2003

Kharel, M.K.; Subba, B.; Lee, H.C.; Liou, K.; Woo, J.S.; Sohng, J.K.

Biotechnol. Lett.

25

2041-2047

661949

15839685

Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis

2005

Yokoyama, K.; Kudo, F.; Kuwahara, M.; Inomata, K.; Tamegai, H.; Eguchi, T.; Kakinuma, K.

J. Am. Chem. Soc.

127

5869-5874

663004

15827636

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterization of an aminotransferase involved in the formation of 2-deoxystreptamine

2005

Huang, F.; Haydock, S.F.; Mironenko, T.; Spiteller, D.; Li, Y.; Spencer, J.B.

Org. Biomol. Chem.

3

1410-1418

672584

15582417

Characterization of L-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius

2005

Kharel, M.K.; Subba, B.; Lee, H.C.; Liou, K.; Sohng, J.K.

Bioorg. Med. Chem. Lett.

15

89-92

719670

16506694

Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773

2005

Kudo, F.; Yamamoto, Y.; Yokoyama, K.; Eguchi, T.; Kakinuma, K.

J. Antibiot.

58

766-774

722025

12478783

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

2002

Huang, F.; Li, Y.; Yu, J.; Spencer, J.B.

Chem. Commun. (Camb. )

2002

2860-2861

723736

16894611

Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

2006

Popovic, B.; Tang, X.; Chirgadze, D.Y.; Huang, F.; Blundell, T.L.; Spencer, J.B.

Proteins

65

220-230

Links to other databases for 2-deoxy-scyllo-inosose

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Show Links (1 entry)

ChEBI

PubChem