Ligand 2-methylcrotonoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of 2-methylcrotonoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H42N7O17P3S
2-methylcrotonoyl-CoA
PMWATMXOQQZNBX-DKBZLLMOSA-N
Synonyms:
(2E)-2-methylcrotonoyl-CoA, (E)-2-methyl-2-butenoyl-CoA, (E)-2-methylbut-2-enoyl-CoA, (E)-2-methylcrotonoyl-CoA, 2-methyl-2-butenoyl-CoA, 2-methyl-corotonyl-CoA, 2-methyl-trans-crotonyl-CoA, 2-methylbut-2-enoyl-CoA, 2-methylcrotonyl-CoA, methyl-crotonyl-CoA, methylcrotonyl-CoA, methylcrotonylCoA, tigloyl-CoA, tiglyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tiglyl-CoA + H2O = 3-hydroxy-2-methylbutanoyl-CoA
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tiglyl-CoA + NAD+ = 3-oxo-2-methylacyl-CoA + NADH
show the reaction diagram
-
2-methyl-trans-crotonyl-CoA + NADPH = 2-methylbutanoyl-CoA + NADP+
show the reaction diagram
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2-methylcrotonyl-CoA + malonyl-[acyl-carrier protein] = (4E)-4-methylhex-4-enoyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
-
tiglyl-CoA + glycine = CoA + N-tiglylglycine
show the reaction diagram
-
tiglyl-CoA + H2O = 3-hydroxy-2-methylbutanoyl-CoA
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+
show the reaction diagram
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methyl-glutaryl-CoA + acceptor = methyl-crotonyl-CoA + reduced acceptor
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
CoA-activated enzyme, competitive inhibition
-
CoA-activated enzyme shows competitive inhibition with the substrate analog 2-methylcrotonyl-CoA
-
competitively inhibits activity with acetyl-CoA
-
weak
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.31
-
30°C, pH 9

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0029
-
-
0.0029
-
pH and temperature not specified in the publication

References & Links

Links to other databases for 2-methylcrotonoyl-CoA

ChEBI
PubChem
ChEBI
PubChem