Ligand DL-homocysteine

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Basic Ligand Information

Molecular Structure
Picture of DL-homocysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2S
DL-homocysteine
FFFHZYDWPBMWHY-UHFFFAOYSA-N
Synonyms:
(DL)-homocysteine, D,L-homocysteine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-homocysteine + 2-oxoglutarate + O2 = ?
show the reaction diagram
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DL-Homocysteine + NADPH + O2 = ?
show the reaction diagram
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S-adenosyl-L-methionine + DL-homocysteine = L-methionine + S-adenosyl-L-homocysteine
show the reaction diagram
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S-adenosyl-L-methionine + DL-homocysteine = ?
show the reaction diagram
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dimethylsulfonioacetate + DL-homocysteine = (methylsulfanyl)acetate + L-methionine
show the reaction diagram
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betaine + DL-homocysteine = dimethylglycine + L-methionine
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glyoxylate + DL-homocysteine = glycine + 2-oxo-4-thiobutanoate
show the reaction diagram
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thiosulfate + D,L-homocysteine = ?
show the reaction diagram
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D,L-Homocysteine = ?
show the reaction diagram
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DL-Homocysteine = 3-Thiopropanamine + CO2
show the reaction diagram
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2-Oxobutanoate + DL-homocysteine = ?
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(DL)-homocysteine = H2S + ?
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DL-homocysteine + H2O = hydrogen sulfide + 2-oxobutyrate + ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-DL-homocysteine + H2O = DL-homocysteine + adenosine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
SH compound required, efficient activator at 25 mM
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at pH 8.2-8.4 as effective as L-Cys
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Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits the enzyme in cardiac tissue of male rats
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strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
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12.5 mM, 70% inhibition, competitive inhibitor
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2.5 mM, 59% residual activity
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competitive
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enzyme YtmJKLMN shows 24% inhibition at 0.05 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0375
-
-

KM Value (43 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.072
-
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5.3
-
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0.008
-
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68
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cosubstrate L-Ser

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.5
-
-

References & Links

Links to other databases for DL-homocysteine

ChEBI
PubChem
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PubChem