Ligand beta-carotene

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Basic Ligand Information

Molecular Structure
Picture of beta-carotene (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C40H56
beta-carotene
OENHQHLEOONYIE-JLTXGRSLSA-N
Synonyms:
all-trans-beta-carotene, alpha-/beta-carotene, beta,beta-carotene


Show all pahtways known for Show all BRENDA pathways known for beta-carotene

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone
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beta-carotene + 2-oxoglutarate + O2 + H2O = canthaxanthin + succinate + CO2 + 4 H+
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beta-carotene + reduced cytochrome P-450 + O2 = zeaxanthin + oxidized cytochrome P-450 + H2O
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beta-carotene + 2 reduced acceptor + 2 O2 = echinenone + 2 acceptor + 3 H2O
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beta-carotene + 2 acceptor = beta-isorenieratene + 2 reduced acceptor
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beta-carotene + 2 acceptor = beta,chi-carotene + 2 reduced acceptor
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all-trans-beta-carotene = 9-cis-beta-carotene
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lycopene = delta-carotene + beta-carotene + alpha-carotene + epsilon-carotene
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Substrate in Enzyme-catalyzed Reactions (48 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-carotene + H+ + H2O2 = ?
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beta-carotene + O2 = 10'-apo-beta-carotenal + beta-ionone
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beta-carotene + O2 = retinal + beta-apo-14'-carotenal + beta-apo-13-carotenone
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beta-carotene + reduced cytochrome P-450 + O2 = zeaxanthin + oxidized cytochrome P-450 + H2O
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beta-carotene + benzoquinone + H2O = echinenone + benzoquinol + 2 H+
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beta-carotene + 2 acceptor = beta,chi-carotene + 2 reduced acceptor
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all-trans-beta-carotene = 9-cis-beta-carotene
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
9-cis-beta-carotene = all-trans-beta-carotene
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lycopene = delta-carotene + beta-carotene + alpha-carotene + epsilon-carotene
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (60 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
increases hydrolytic activity
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Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
in absence of other lipids, inhibits chlorophyl a conversion
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mixture of alpha- and beta-form, 64.4% inhibition at 0.5 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (113 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1000
-
at 30C and pH 4.5
0.0087
-
pH 6.8, 20C

KM Value (35 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
at 30C and pH 4.5
0.0104
-
pH 6.8, 20C
0.0152
-
pH 7.0, temperature not specified in the publication
0.0013
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30C, 0.4 M Tris/HCl, pH 8.0, 1 mM dithiothreitol, 0.5 mM FeSO4, 5 mM ascorbic acid, 0.5 mM 2-oxoglutarate, 0.1% (mass/vol) deoxycholate
0.0025
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in 0.4 M Tris/HCl, pH 8.0, at 30C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0078
-
-

References & Links

Links to other databases for beta-carotene

ChEBI
PubChem
ChEBI
PubChem