Ligand 7-dehydro-17alpha-hydroxypregnenolone
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Basic Ligand Information
Molecular Structure

C21H30O3
7-dehydro-17alpha-hydroxypregnenolone
GHQXOGDXOSLAQM-SFOIOBPVSA-N
7-dehydro-17alpha-hydroxy-pregnenolone
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 = 7-dehydro-dehydroepiandrosterone + acetate + A + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)
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7-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2 = 7-dehydro-17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
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7-dehydro-pregnenolone + AH2 + O2 = 7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O
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7-dehydro-pregnenolone + AH2 + O2 = 7-dehydro-17alpha-hydroxypregnenolone + A + H2O
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Substrate in Enzyme-catalyzed Reactions (1 result)
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7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 = 7-dehydro-dehydroepiandrosterone + acetate + A + H2O
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Product in Enzyme-catalyzed Reactions (3 results)
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7-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2 = 7-dehydro-17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
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7-dehydro-pregnenolone + AH2 + O2 = 7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O
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7-dehydro-pregnenolone + AH2 + O2 = 7-dehydro-17alpha-hydroxypregnenolone + A + H2O
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17
2011
Gilep, A.A.; Sushko, T.A.; Usanov, S.A.
Biochim. Biophys. Acta
1814
200-209
The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay
2013
Roelofs, M.J.; Piersma, A.H.; van den Berg, M.; van Duursen, M.B.
Toxicol. Appl. Pharmacol.
268
309-317
Links to other databases for 7-dehydro-17alpha-hydroxypregnenolone