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Ligand reduced cytochrome c

Basic Ligand Information

Pathway Source

Pathways

BRENDA

oxidative phosphorylation

KEGG

Oxidative phosphorylation, Porphyrin and chlorophyll metabolism

MetaCyc

2-deoxy-D-ribose degradation II, aerobic respiration I (cytochrome c), aerobic respiration II (cytochrome c) (yeast), ammonia oxidation I (aerobic), ammonia oxidation II (anaerobic), arsenite oxidation I (respiratory), butane degradation, cytochrome c biogenesis (system I type), cytochrome c biogenesis (system II type), cytochrome c biogenesis (system III type), Fe(II) oxidation, L-ascorbate biosynthesis I (plants, L-galactose pathway), L-ascorbate biosynthesis II (plants, L-gulose pathway), L-ascorbate biosynthesis VI (plants, myo-inositol pathway), L-ascorbate biosynthesis VII (plants, D-galacturonate pathway), methylglyoxal degradation V, methylglyoxal degradation VI, methylglyoxal degradation VIII, nitrate reduction I (denitrification), nitrate reduction IV (dissimilatory), nitrate reduction VII (denitrification), nitrifier denitrification, nitrite oxidation, nitrite-dependent anaerobic methane oxidation, phenylethanol degradation, polyvinyl alcohol degradation, sulfide oxidation II (flavocytochrome c), sulfite oxidation I, thiocyanate degradation I, thiosulfate oxidation I (to tetrathionate), thiosulfate oxidation III (multienzyme complex), thiosulfate oxidation IV (multienzyme complex) more

Show all BRENDA pathways known for reduced cytochrome c

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

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Show Natural Product (7 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.20.99.1

arsenite + cytochrome c + H2O = arsenate + reduced cytochrome c

-

-

1.3.2.3

L-galactono-1,4-lactone + cytochrome c = L-ascorbate + reduced cytochrome c

-

-

1.4.99.2

taurine + H2O + cytochrome c = sulfoacetaldehyde + NH3 + reduced cytochrome c

-

-

1.6.2.4

NADPH + H+ + cytochrome c = NADP+ + reduced cytochrome c

-

-

1.6.5.10

NADPH + H+ + cytochrome c = NADP+ + reduced cytochrome c

-

-

1.8.2.2

thiosulfate + cytochrome c = tetrathionate + reduced cytochrome c

394120, 288769

-

1.8.3.1

sulfite + cytochrome c = sulfate + reduced cytochrome c

-

-

Substrate in Enzyme-catalyzed Reactions (10 results)

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Show Substrate (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.21

reduced cytochrome c + H2O2 = oxidized cytochrome c + H2O

439789

-

1.11.1.6

reduced cytochrome c + H2O2 = oxidized cytochrome c + H2O

439789

-

1.15.1.2

reduced cytochrome c + superoxide + 2 H+ = oxidized cytochrome c + H2O2

727470

-

1.15.1.2

reduced cytochrome c + superoxide + H+ = cytochrome c + H2O2

390148, 390159, 390149, 390150

-

1.15.1.2

2 entries

1.18.1.2

reduced cytochrome c + NADPH + H+ = oxidized cytochrome c + NADPH

743411

-

1.7.2.4

N2O + reduced cytochrome c = N2 + H2O + cytochrome c

673234

-

1.7.2.5

nitric oxide + reduced cytochrome c = nitrous oxide + cytochrome c + H2O

672672

-

1.7.2.5

O2 + reduced cytochrome c = H2O + cytochrome c

671964

-

1.7.2.5

2 entries

1.8.3.2

dithiothreitol + reduced cytochrome c = dithiothreitol disulfide + oxidized cytochrome c

658104

-

7.1.1.9

reduced cytochrome c + O2 + H+ = oxidized cytochrome c + H2O

692992, 689159, 692708, 693451, 694175, 694379, 694592, 694959, 690457, 691335, 693006

-

Product in Enzyme-catalyzed Reactions (52 results)

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Show Product (52 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.404

cytochrome c + NADPH + H+ = reduced cytochrome c + NADP+

-

-

1.1.3.18

polyvinyl alcohol + cytochrome c = polyvinylketone + reduced cytochrome c

-

-

1.1.9.1

ethanol + cytochrome c = ethanal + reduced cytochrome c

-

-

1.1.99.18

cellobiose + cytochrome c = cellobiono-1,5-lactone + reduced cytochrome c

-

-

1.1.99.18

lactose + cytochrome c = 4-O-(beta-D-galactopyranosyl)-D-glucono-1,5-lactone + reduced cytochrome c

-

-

1.1.99.18

lactose + cytochrome c = lactobiono-1,5-lactone + reduced cytochrome c

-

-

1.1.99.18

lactose + cytochrome c = lactono-1,5-lactone + reduced cytochrome c

-

-

1.1.99.18

4 entries

1.14.13.25

cytochrome c + NAD(P)H + O2 = reduced cytochrome c + NAD(P)+ + H2O

-

-

1.14.13.39

oxidized cytochrome c + NADPH + O2 = reduced cytochrome c + NADP+ + H2O

-

-

1.14.14.1

toluene + O2 + NAD(P)H + cytochrome c = benzyl alcohol + H2O + NAD(P)+ + reduced cytochrome c

-

-

1.17.1.4

hypoxanthine + cytochrome c + H2O = xanthine + reduced cytochrome c

644616

-

1.17.1.4

xanthine + cytochrome c + H2O = urate + reduced cytochrome c

644580, 644570, 644587, 644597

-

1.17.1.4

2 entries

1.17.1.9

formate + cytochrome c = CO2 + reduced cytochrome c

-

-

1.17.3.2

xanthine + cytochrome c + H2O = urate + reduced cytochrome c

-

-

1.18.1.2

NADPH + oxidized cytochrome c = NADP+ + reduced cytochrome c

-

-

1.18.1.2

oxidized ferredoxin + NADH + cytochrome c = reduced ferredoxin + NAD+ + reduced cytochrome c

-

-

1.18.1.2

oxidized ferredoxin + NADPH + cytochrome c = reduced ferredoxin + NADP+ + reduced cytochrome c

-

-

1.18.1.2

phenyl-p-benzoquinone + NADPH + cytochrome c = ? + NADP+ + reduced cytochrome c

-

-

1.18.1.2

4 entries

1.18.1.3

NADPH + oxidized cytochrome c = NADP+ + reduced cytochrome c

-

-

1.18.1.7

oxidized cytochrome c + NADPH = reduced cytochrome c + NADP+ + H+

-

-

1.19.1.1

oxidized cytochrome c + NADH + H+ = reduced cytochrome c + NAD+

-

-

1.19.1.1

oxidized cytochrome c + NADPH + H+ = reduced cytochrome c + NADP+

-

-

1.19.1.1

2 entries

1.2.7.10

oxalate + cytochrome c = CO2 + reduced cytochrome c

-

-

1.2.99.7

benzaldehyde + H2O + cytochrome c = benzoate + reduced cytochrome c

-

-

1.20.2.1

arsenite + cytochrome c + H2O = arsenate + reduced cytochrome c

-

-

1.20.99.1

arsenite + cytochrome c + H2O = arsenate + reduced cytochrome c

-

-

1.3.2.3

L-galactono-1,4-lactone + cytochrome c = L-ascorbate + reduced cytochrome c

-

-

1.4.99.2

taurine + H2O + cytochrome c = sulfoacetaldehyde + NH3 + reduced cytochrome c

-

-

1.5.5.2

L-proline + cytochrome c = (S)-1-pyrroline-5-carboxylate + reduced cytochrome c

-

-

1.5.5.3

trans-4-hydroxy-L-proline + cytochrome c = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + reduced cytochrome c

-

-

1.5.99.12

N6-(2-isopentenyl)adenine + cytochrome c = adenine + 3-methylbut-2-enal + reduced cytochrome c

-

-

1.5.99.5

N-methylglutamate + cytochrome c + H2O = L-glutamate + formaldehyde + reduced cytochrome c

-

-

1.5.99.B2

L-proline + cytochrome c + H2O = (S)-1-pyrroline-5-carboxylate + reduced cytochrome c

-

-

1.6.2.2

NADH + oxidized cytochrome c = NAD+ + H+ + reduced cytochrome c

-

-

1.6.2.4

NADPH + H+ + cytochrome c = NADP+ + reduced cytochrome c

-

-

1.6.2.4

NADPH + H+ + oxidized cytochrome c = NADP+ + reduced cytochrome c

-

-

1.6.2.4

2 entries

1.6.5.10

NADPH + H+ + cytochrome c = NADP+ + reduced cytochrome c

-

-

1.7.1.6

NADPH + oxidized cytochrome c = NADP+ + reduced cytochrome c

394297

-

1.8.1.9

cytochrome c + NADPH = reduced cytochrome c + NADP+

-

-

1.8.2.2

thiosulfate + cytochrome c = tetrathionate + reduced cytochrome c

394120, 288769

-

1.8.2.3

sulfide + oxidized cytochrome c = sulfur + reduced cytochrome c + H+

-

-

1.8.3.1

sulfite + cytochrome c = sulfate + reduced cytochrome c

-

-

1.8.3.3

dithiothreitol + cytochrome c = dithiothreitol disulfide + reduced cytochrome c

-

-

7.1.1.8

tetramethyl-p-benzoquinol + cytochrome c = tetramethyl-p-benzoquinone + reduced cytochrome c

-

-

7.1.1.8

ubideuteroquinol + cytochrome c = ubideuteroquinone + reduced cytochrome c

-

-

7.1.1.8

ubihydroquinol + cytochrome c = ubihydroquinone + reduced cytochrome c

-

-

7.1.1.8

ubiquinol 10 + cytochrome c = ubiquinone 10 + reduced cytochrome c

-

-

7.1.1.8

ubiquinol 2 + cytochrome c = ubiquinone 2 + reduced cytochrome c

-

-

7.1.1.8

ubiquinol 3 + cytochrome c = ubiquinone 3 + reduced cytochrome c

-

-

7.1.1.8

ubiquinol 4 + cytochrome c = ubiquinone 4 + reduced cytochrome c

-

-

7.1.1.8

ubiquinol 9 + cytochrome c = ubiquinone 9 + reduced cytochrome c

-

-

7.1.1.8

ubiquinol-1 + cytochrome c = ubiquinone-1 + reduced cytochrome c

-

-

7.1.1.8

9 entries

Enzyme Kinetic Parameters

References & Links

Literature References (30)

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Show Reference (30 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

288769

-

Cellular location and partial purification of the 'thiosulphate-oxidizing enzyme' and the 'trithionate hydrolase' from Thiobacillus tepidarius

1988

Lu, W.P.; Kelly, D.P.

J. Gen. Microbiol.

134

877-885

390148

10514376

Anaerobic microbes: oxygen detoxification without superoxide dismutase

1999

Jenney, F.E., Jr.; Verhagen, M.F.J.M.; Cui, X.; Adams, M.W.W.

Science

286

306-309

390149

10874033

Neelaredoxin, an iron-binding protein from the syphilis spirochete, Treponema pallidum, is a superoxide reductase

2000

Jovanovic, T.; Ascenso, C.; Hazlett, K.R.O.; Sikkink, R.; Krebs, C.; Litwiller, R.; Benson, L.M.; Moura, I.; Moura, J.J.G.; Radolf, J.D.; Huynh, B.H.; Naylor, S.; Rusnak, F.

J. Biol. Chem.

275

28439-28448

390150

10617593

Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity

2000

Lombard, M.; Fontecave, M.; Touati, D.; Niviere, V.

J. Biol. Chem.

275

115-121

390159

11912914

Superoxide reductase activities of neelaredoxin and desulfoferrodoxin metalloproteins

2002

Rusnak, F.; Ascenso, C.; Moura, I.; Moura, J.J.G.

Methods Enzymol.

349

243-258

394120

4215368

Mechanisms of inorganic oxidation and energy coupling

1974

Suzuki, I.

Annu. Rev. Microbiol.

28

85-101

394297

91608

Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme

1979

Huang, M.T.; Miwa, G.T.; Cronheim, N.; Lu, A.Y.H.

J. Biol. Chem.

254

11223-11227

439789

8320233

Purification of a catalase-peroxidase from Halobacterium halobium: Characterization of some unique properties of the halophilic enzyme

1993

Brown-Petersen, N.J.; Salin, M.L.

J. Bacteriol.

175

4197-4202

644570

8706691

Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor

1996

Gremer, L.; Meyer, O.

Eur. J. Biochem.

238

862-866

644580

176939

Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase

1976

Waud, W.R.; Rajagopalan, K.V.

Arch. Biochem. Biophys.

172

354-364

644587

176940

The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O)

1976

Waud, W.R.; Rajagopalan, K.V.

Arch. Biochem. Biophys.

172

365-379

644597

6061702

Purification and properties of xanthine dehydrogenase from Micrococcus lactilyticus

1967

Smith, S.T.; Rajagopalan, K.V.; Handler, P.

J. Biol. Chem.

242

4108-4117

644616

479130

Purification and properties of xanthine dehydrogenase from Streptomyces cyanogenus

1979

Ohe, T.; Watanabe, Y.

J. Biochem.

86

45-53

658104

15683237

Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity

2005

Farrell, S.R.; Thorpe, C.

Biochemistry

44

1532-1541

671964

16060680

Electron/proton coupling in bacterial nitric oxide reductase during reduction of oxygen

2005

Flock, U.; Watmough, N.J.; Adelroth, P.

Biochemistry

44

10711-10719

672672

16861801

Gene structure and expression profile of cytochrome bc nitric oxide reductase from Hydrogenobacter thermophilus TK-6

2006

Suzuki, M.; Arai, H.; Ishii, M.; Igarashi, Y.

Biosci. Biotechnol. Biochem.

70

1666-1671

673234

16234931

Formation of a cytochrome c-nitrous oxide reductase complex is obligatory for N2O reduction by Paracoccus pantotrophus

2005

Rasmussen, T.; Brittain, T.; Berks, B.C.; Watmough, N.J.; Thomson, A.J.

Dalton Trans.

2005

3501-3506

689159

17673979

Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain

2007

Streck, E.L.; Rezin, G.T.; Barbosa, L.M.; Assis, L.C.; Grandi, E.; Quevedo, J.

Naunyn Schmiedebergs Arch. Pharmacol.

376

127-133

690457

17283192

Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes

2007

Luque-Ortega, J.R.; Rivas, L.

Antimicrob. Agents Chemother.

51

1327-1332

691335

18441024

In situ monitoring of the catalytic activity of cytochrome C oxidase in a biomimetic architecture

2008

Friedrich, M.G.; Plum, M.A.; Santonicola, M.G.; Kirste, V.U.; Knoll, W.; Ludwig, B.; Naumann, R.L.

Biophys. J.

95

1500-1510

692708

18379993

Nitric oxide irreversibly inhibits cytochrome oxidase at low oxygen concentrations: evidence for inverse oxygen concentration-dependent peroxynitrite formation

2008

Parihar, A.; Vaccaro, P.; Ghafourifar, P.

IUBMB Life

60

64-67

692992

17452320

An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria

2007

Li, Y.; DAurelio, M.; Deng, J.H.; Park, J.S.; Manfredi, G.; Hu, P.; Lu, J.; Bai, Y.

J. Biol. Chem.

282

17557-17562

693006

17690099

Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state

2007

Borutaite, V.; Brown, G.C.

J. Biol. Chem.

282

31124-31130

693451

17202348

HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons

2007

Norman, J.P.; Perry, S.W.; Kasischke, K.A.; Volsky, D.J.; Gelbard, H.A.

J. Immunol.

178

869-876

694175

18541608

Phosphorylation and kinetics of mammalian cytochrome c oxidase

2008

Helling, S.; Vogt, S.; Rhiel, A.; Ramzan, R.; Wen, L.; Marcus, K.; Kadenbach, B.

Mol. Cell. Proteomics

7

1714-1724

694379

17320290

Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner

2007

Jung, M.E.; Agarwal, R.; Simpkins, J.W.

Neurosci. Lett.

416

160-164

694592

18198996

Ischemia-reperfusion induces inhibition of mitochondrial protein synthesis and cytochrome C oxidase activity in rat hippocampus

2008

Racay, P.; Tatarkova, Z.; Drgova, A.; Kaplan, P.; Dobrota, D.

Physiol. Res.

58

127-138

694959

17910921

Biophysical and biochemical characterization of reconstituted and purified Rhodobacter sphaeroides cytochrome c oxidase in phospholipid vesicles sheds insight into its functional oligomeric structure

2007

Cvetkov, T.L.; Prochaska, L.J.

Protein Expr. Purif.

56

189-196

727470

21138528

Methanoferrodoxin represents a new class of superoxide reductase containing an iron-sulfur cluster

2011

Krätzer, C.; Welte, C.; Dörner, K.; Friedrich, T.; Deppenmeier, U.

FEBS J.

278

442-451

743411

25698107

Replacement of Tyr50 stacked on the si-face of the isoalloxazine ring of the flavin adenine dinucleotide prosthetic group modulates Bacillus subtilis ferredoxin-NADP+ oxidoreductase activity toward NADPH

2015

Seo, D.; Naito, H.; Nishimura, E.; Sakurai, T.

Photosyn. Res.

125

321-328

Links to other databases for reduced cytochrome c

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Show Links (1 entry)

ChEBI

PubChem

-

-

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Release 2021.2 (July 2021)
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